{"ok":true,"nota":{"id":"67ab54404b447df2","slug":"los-genes-asociados-a-depresion-esquizofrenia-y-bipolaridad-influyen-e-67ab54","titulo":"Los genes asociados a depresión, esquizofrenia y bipolaridad influyen en qué tan bien responde cada paciente","resumen":"Un equipo analizó a más de 4.000 pacientes europeos de siete cohortes para ver si el riesgo genético de cuatro trastornos psiquiátricos predice la respuesta al tratamiento. Combinaron los resultados de todos los grupos.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Serretti, A.","url":"https://www.medrxiv.org/content/10.64898/2026.10.22.26366267v1?rss=1","imagen":"/hoy/portada/67ab54404b447df2","tema":"ciencia","subtemas":["genética","salud mental","depresión","tratamientos psiquiátricos","medicina personalizada"],"entidades":["STAR*D","CATIE","STEP-BD","Barcelona"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T20:03:50.039Z","hash":"4d7f90a8fe05f92229c9ba1b02bd1a009d2db5cc303ee8b0768585f5672e40dd","tsa":{"time":"Oct 26 20:04:12 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Un puntaje de riesgo genético de depresión se asocia con peor respuesta al tratamiento, lo que sugiere que parte de por qué un antidepresivo funciona en una persona y no en otra está escrita en su ADN. Para quien vive con un diagnóstico así, esto no reemplaza la consulta, pero en el futuro podría ayudar a elegir tratamientos sin tanto ensayo y error. Todavía el resultado es un promedio poblacional, no un examen para una persona concreta.","quienFirma":"Consorcio de estudios genómicos psiquiátricos (cohortes STAR*D, CATIE, STEP-BD y otras)","confianza":"preprint","consulta":null},"sello":{"hash":"4d7f90a8fe05f92229c9ba1b02bd1a009d2db5cc303ee8b0768585f5672e40dd","sello":"ce89a5ef3307ed0a516fed01444fb4cbc3a5eea6c7a6c81af0f3bd8dc249470d","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6587133,"aleatorio":"dc324b08f0f2561bca711f2c376451dc2f1171a6b816a539d57904b5c4cb0056","tiempo":"2026-10-26T20:03:30.000Z"},"nist":{"cadena":2,"pulso":2000760,"salida":"94054E94B60B549ECC074DB2FF32049D9C63F7D049ACA947173CD97D409323329B9AC702822A4BD77D88E442608FFE9345A5A7931C7B12D80ED0D14122E7FBBC","tiempo":"2026-10-26T20:03:00.000Z"},"noAntes":"2026-10-26T20:03:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 20:04:12 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Polygenic liability for major depression, schizophrenia and bipolar disorder and treatment outcome across major psychiatric disorders","descripcion":"Polygenic scores for major depression, schizophrenia and bipolar disorder have been related to treatment outcome. We analysed 4,007 patients of European ancestry from 7 cohorts: three with major depression (STAR*D, GSRD, PANDORA), two with bipolar disorder (STEP-BD, Barcelona) and two with schizophrenia (CATIE, HSRRm). The three scores were computed with PRS-CS from the latest Psychiatric Genomics Consortium studies. The primary outcome was good response or good course, harmonized from each cohort's instrument. Firth logistic regression within cohorts, adjusted for age, sex and ancestry components, was followed by random-effects pooling. A higher depression score was associated with lower od","pubDate":"2026-10-26","url":"https://www.medrxiv.org/content/10.64898/2026.10.22.26366267v1?rss=1"},"indexado":"2026-10-26T20:03:50.039Z"}}