{"ok":true,"nota":{"id":"66382c96489fae0f","slug":"logran-obtener-celulas-parecidas-al-higado-a-partir-de-celulas-madre-d-66382c","titulo":"Logran obtener células parecidas al hígado a partir de células madre de oveja","resumen":"Desarrollaron un método sin suero para convertir células madre embrionarias de oveja en células similares a las del hígado. Estas células produjeron albúmina y procesaron grasas, y mostraron un patrón genético propio de la especie.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Kok, F. O., Kasarinaite, A., Rajesh, D., Mee, P. J., Hay, D. C.","url":"https://www.biorxiv.org/content/10.64898/2026.10.23.761310v1?rss=1","imagen":"/hoy/portada/66382c96489fae0f","tema":"ciencia","subtemas":["células madre","hígado","ganadería","biotecnología animal","modelos de laboratorio"],"entidades":["ovejas"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T20:03:50.039Z","hash":"0b336a79c7733698b6aee9c2d7ff8dd8a4e2dd1915a3e83025b7ffe7e7ba3755","tsa":{"time":"Oct 26 20:04:15 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Crear hígados en laboratorio con animales de granja puede servir para estudiar enfermedades y probar medicamentos sin usar tantos animales vivos. En un país con fuerte producción ganadera como el nuestro, también abre preguntas sobre sanidad y biotecnología animal. Para la gente común, es un paso hacia pruebas de fármacos más éticas y más baratas. Aun así, es un modelo en células, no un órgano completo.","quienFirma":"bioRxiv (preprint; institución de los autores no especificada en el resumen)","confianza":"preprint","consulta":null},"sello":{"hash":"0b336a79c7733698b6aee9c2d7ff8dd8a4e2dd1915a3e83025b7ffe7e7ba3755","sello":"5d79e2e499d065a06ea5077f9b9088e6206a3e0fae518911bf966cc505e59b37","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6587133,"aleatorio":"dc324b08f0f2561bca711f2c376451dc2f1171a6b816a539d57904b5c4cb0056","tiempo":"2026-10-26T20:03:30.000Z"},"nist":{"cadena":2,"pulso":2000760,"salida":"94054E94B60B549ECC074DB2FF32049D9C63F7D049ACA947173CD97D409323329B9AC702822A4BD77D88E442608FFE9345A5A7931C7B12D80ED0D14122E7FBBC","tiempo":"2026-10-26T20:03:00.000Z"},"noAntes":"2026-10-26T20:03:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 20:04:15 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Generation of hepatocyte-like cells from sheep embryonic stem cells","descripcion":"Development of in-vitro liver models in livestock species presents new opportunities for studying animal physiology and expanding biotechnological applications. Here, we describe a serum-free differentiation strategy to generate hepatocyte-like cells (HLCs) from sheep embryonic stem cells (ESCs). The HLCs displayed hepatocyte morphology and key hepatic functions such as albumin secretion, inducible P450 activity, lipid uptake and storage. Transcriptomic analysis further confirmed progressive hepatic specification and revealed both conserved and species-specific gene expression patterns. Overall, this study establishes a robust system for generating sheep HLCs and offers a platform for studyi","pubDate":"2026-10-26","url":"https://www.biorxiv.org/content/10.64898/2026.10.23.761310v1?rss=1"},"indexado":"2026-10-26T20:03:50.039Z"}}