{"ok":true,"nota":{"id":"63c993b3cebd8af2","slug":"cientificos-descubren-una-enzima-que-fabrica-moleculas-con-forma-de-an-63c993","titulo":"Científicos descubren una enzima que fabrica moléculas con forma de anillo doble en péptidos","resumen":"Investigadores de Australia y otros países identificaron dos enzimas bacterianas que unen partes de pequeñas cadenas de aminoácidos formando estructuras cerradas. Una de ellas, AscB, logra crear un segundo anillo además del primero. El trabajo se hizo con bacterias modificadas en laboratorio.","fuente":"zenodo","fuenteNombre":"Zenodo · Investigación abierta","color":"#1682d4","autor":"Haedar, Jabal Rahmat, Khan, Abujunaid Habib, Gullick, Jemma","url":"https://doi.org/10.1021/acs.orglett.6c01044","imagen":"/hoy/portada/63c993b3cebd8af2","tema":"ciencia","subtemas":["biosíntesis","bacterias","péptidos","enzimas","química orgánica"],"entidades":["Amycolatopsis sacchari","Micromonospora","AscB","MmsB"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T04:30:29.000Z","indexTs":"2026-10-22T22:31:26.228Z","hash":"6c4d29e3a7c482a3efa63dcd64df82dfc5e9b54e0b7d74b3ff9452278bb9e055","tsa":{"time":"Oct 22 22:32:23 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Estas moléculas pertenecen a una familia de compuestos que las bacterias producen de forma natural y que a veces tienen actividad antibiótica o antitumoral. Conocer qué enzima hace cada cierre abre la puerta a fabricar variantes en el laboratorio. Eso no significa que haya un fármaco a la vuelta de la esquina, porque el camino entre una molécula nueva y un medicamento es largo. Para el lector argentino, es un recordatorio de cuánto de la farmacia moderna empieza en un microbio del suelo.","quienFirma":"Universidad de Adelaida y colaboradores internacionales","confianza":"revisado","consulta":null},"sello":{"hash":"6c4d29e3a7c482a3efa63dcd64df82dfc5e9b54e0b7d74b3ff9452278bb9e055","sello":"3b3ba93da682906f437d8961af1a7c35cc1dd605e2ac316d52f57b827f3a425d","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575910,"aleatorio":"ad632c470ba8c968ea920b116993e6a501688139a43318de64f5a7ea72e81de2","tiempo":"2026-10-22T22:32:00.000Z"},"nist":{"cadena":2,"pulso":1995154,"salida":"A32727015042185E787530FED53F828C26131B55C644F3F364155FFBAB02AAA2930B78FFEE6913417A86FA34480E1F05FB9B4984B59D1A0E007BB8E6E3A95F8F","tiempo":"2026-10-22T22:31:00.000Z"},"noAntes":"2026-10-22T22:32:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 22:32:23 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"P450 Cyptide Synthase AscB Catalyzes Fused Cyclophane at the YxWxH Motif on the Precursor Peptides","descripcion":"<p>Haedar J. R., Khan A. H., Gullick J., Hansen M. H., Coe L. J., De Voss J. J., Romanuks V., Smits G., Donadio S., Cryle M. J., Phan C.-S. <em>Org. Lett</em>. <strong>2026</strong>, 28, 5966-5971. <strong>Abstract</strong>: Cyptides are a new class of ribosomally synthesized and post-translationally modified peptides (RiPPs) with the unique feature of biaryl C&ndash;C, C&ndash;N, or C&ndash;O cross-links formed by P450 cyptide synthases (P450s). Through functional studies in <em>Escherichia coli</em>, we discovered two newly identified P450 enzymes, AscB from <em>Amycolatopsis sacchari</em> DSM 44468 and MmsB from <em>Micromonospora</em> sp. HM5-17, that can catalyze the cross-linking between Tyr-C3 and Trp-N1, as well as the hydroxylation at Trp-C5 in the YxWxH motif. However, only AscB was able to catalyze the formation of a second cyclophane between Trp-C4 and His-N&tau;, generating ","pubDate":"2026-10-20T04:30:29Z","url":"https://doi.org/10.1021/acs.orglett.6c01044"},"indexado":"2026-10-22T22:31:26.228Z"}}