{"ok":true,"nota":{"id":"629c738eb6b2d75f","slug":"un-analgesico-con-ketamina-no-mostro-que-la-dosis-de-opioide-siga-una--629c73","titulo":"Un analgésico con ketamina no mostró que la dosis de opioide siga una lógica simple del dolor","resumen":"Investigadores analizaron pacientes operados de columna que se autoadministraban oxicodona con o sin S-ketamina durante 24 horas. Midieron cuánto medicamento llegaba a la sangre y cómo se relacionaba con el dolor que referían en cada momento.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Virtanen, T., Brinck, E. C. V., Engstrom, M., Kurkela, M. J., Tarkkila, P., Backman, J., Tornio, A., Kontinen, V., Pelto","url":"https://www.medrxiv.org/content/10.64898/2026.10.20.26365979v1?rss=1","imagen":"/hoy/portada/629c738eb6b2d75f","tema":"salud","subtemas":["dolor postoperatorio","opioides","cirugía de columna","ketamina","analgesia controlada por el paciente"],"entidades":["medRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T22:39:37.287Z","hash":"0f08d0e642c5c1aab358c4da29a59017156b06109f59ee7de6f9013386c0d27d","tsa":{"time":"Oct 21 22:40:35 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"motor","registro":"hallazgo","porQueImporta":"Lo que se registró fue que la cantidad de droga en sangre varió mucho de una persona a otra, aunque subía rápido al empezar el tratamiento. Para quien pasa por una cirugía de columna, esto sugiere que la misma dosis puede aliviar a unos y dejar a otros con dolor, y que no alcanza con prescribir siempre lo mismo. Ojo: es un análisis secundario con pocos pacientes, así que todavía no sirve para cambiar cómo se dosifica en un hospital.","quienFirma":"Universidad no identificada en el resumen (preprint en medRxiv)","confianza":"preprint","consulta":{"pregunta":"¿Un calmante que se controla uno mismo debería dosificarse igual para todos?"}},"sello":{"hash":"0f08d0e642c5c1aab358c4da29a59017156b06109f59ee7de6f9013386c0d27d","sello":"bc25bab3c54ba2afceaff9d985653a89e2ef2695c007b84e0376ae47b43dd5f5","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573046,"aleatorio":"f71b3db032f12c8ae2d90f38aa37ddc03a4bd072f8a3317f2962e831c62e695d","tiempo":"2026-10-21T22:40:00.000Z"},"nist":{"cadena":2,"pulso":1993728,"salida":"DBB029F00A75EEAA9AF69BB0B3207AD12D5A4EDD2136CB35D25CB332980962472F1AFBB0B247EB7DF6BE52045BC8A63F1D14E2719075ECD2BA39DE673005A0E1","tiempo":"2026-10-21T22:39:00.000Z"},"noAntes":"2026-10-21T22:40:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 22:40:35 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Drug exposure during oxycodone-S-ketamine patient-controlled analgesia reflects pain-related dosing behaviour after lumbar fusion surgery","descripcion":"Background: Opioids remain the cornerstone of acute postoperative pain management but are associated with potentially serious adverse effects. We aimed to investigate the effect of oxycodone patient-controlled analgesia with adjunctive S-ketamine on pain after lumbar fusion surgery. Methods: In this secondary analysis, we examined oxycodone and S-ketamine exposure and PCA behaviour during the first 24 h. We assessed current pain versus subsequent PCA activity and whether the association between plasma oxycodone and adequate analgesia changed with postoperative time. Results: Plasma concentrations of administered drugs rose rapidly after PCA initiation, but variation was large. Metabolite con","pubDate":"2026-10-21","url":"https://www.medrxiv.org/content/10.64898/2026.10.20.26365979v1?rss=1"},"indexado":"2026-10-21T22:39:37.287Z"}}