{"ok":true,"nota":{"id":"5b0e7d2c2a8f4e41","slug":"en-ratones-con-alzheimer-bloquear-una-proteina-de-las-celulas-de-soste-5b0e7d","titulo":"En ratones con Alzheimer, bloquear una proteína de las células de sostén redujo las placas y protegió las cone","resumen":"Investigadores estudiaron ratones modificados para tener Alzheimer y eliminaron, en un tipo de célula de soporte del cerebro, una variante de un receptor que frena la señal de una proteína clave para la salud neuronal. Observaron menos placas de amiloide y menos pérdida de sinapsis.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Bass, R., Masterson, H., Chen, Y., Xu, B.","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760443v1?rss=1","imagen":"/hoy/portada/5b0e7d2c2a8f4e41","tema":"ciencia","subtemas":["alzheimer","neurociencia","bdnf","astrocitos","investigacion-en-animales"],"entidades":["bioRxiv","ratones 5xFAD"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-24T00:00:00.000Z","indexTs":"2026-10-25T04:24:55.455Z","hash":"d9d397b9ea49916db31f4ec73adb442f31cacd0f51e1d97a139d4fea73098fe8","tsa":{"time":"Oct 25 04:25:24 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"En los ratones, al bloquear la variante truncada del receptor TrkB en los astrocitos, bajaron las placas de amiloide y se conservaron mejor las sinapsis, que son las conexiones que permiten recordar y pensar. Esto abre una vía de investigación, pero el hallazgo es preliminar y se hizo en animales, así que todavía no hay nada que cambie el tratamiento de una persona. Ojo: lo que funciona en un ratón muchas veces no llega a funcionar en un humano.","quienFirma":"bioRxiv (preprint; institución principal no especificada en la fuente)","confianza":"preprint","consulta":null},"sello":{"hash":"d9d397b9ea49916db31f4ec73adb442f31cacd0f51e1d97a139d4fea73098fe8","sello":"f02d8a79fe85913e1b35965018561106e29e6a284dc739151290bc29eee88870","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6582376,"aleatorio":"943924fd08c86184ef48658c1f2ba176965fdee21d2186f9833e7a4b67426410","tiempo":"2026-10-25T04:25:00.000Z"},"nist":{"cadena":2,"pulso":1998381,"salida":"563FBECEE771809F9BAFDA6308DF1DFE7F8F676E63120C0E21F0FBC1AE1C44F6835AC70B14A6317EDC305695BFEFBCF9F54F36C4F9BCDF744000F6BCB6154829","tiempo":"2026-10-25T04:24:00.000Z"},"noAntes":"2026-10-25T04:25:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 25 04:25:24 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Astrocytic ablation of truncated TrkB receptors reduces amyloid plaques and prevents synaptic loss in 5xFAD mice","descripcion":"Brain-derived neurotrophic factor (BDNF) is essential for nervous system development and function and exerts its effects primarily through the tropomyosin receptor kinase B (TrkB). The Ntrk2 gene encodes a full-length receptor (TrkB.FL) and two truncated isoforms (TrkB.T1 and TrkB.T2, collectively TrkB.T) that lack the intracellular tyrosine kinase domain. TrkB.T is expressed predominantly in astrocytes and is thought to inhibit BDNF-TrkB.FL signaling by sequestering BDNF and forming signaling-deficient heterodimers with TrkB.FL. Here, we investigated whether selective ablation of astrocytic TrkB.T could ameliorate Alzheimer's disease (AD) pathology by enhancing endogenous BDNF-TrkB.FL signa","pubDate":"2026-10-24","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760443v1?rss=1"},"indexado":"2026-10-25T04:24:55.455Z"}}