{"ok":true,"nota":{"id":"5a74c490f112ffd8","slug":"las-celulas-de-la-piel-pueden-volver-a-un-estado-inicial-pero-no-todas-5a74c4","titulo":"Las células de la piel pueden volver a un estado inicial, pero no todas lo logran igual","resumen":"Científicos siguieron cómo células de la piel de cuatro personas se transforman en células madre, comparando los cambios en los genes y en la organización del ADN. Observaron que las diferencias entre las células de origen eran más marcadas dentro de cada persona que entre personas distintas.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Li, T. W., Langerman, J., Liu, C., Sun, Y., Baig, M. S., Kim, G., Fu, J., Ghoor, R. I., Zhang, Y., Von Behren, Z., Tsai,","url":"https://www.biorxiv.org/content/10.64898/2026.10.15.757424v1?rss=1","imagen":"/hoy/portada/5a74c490f112ffd8","tema":"ciencia","subtemas":["células madre","epigenética","reprogramación celular","medicina regenerativa"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-22T04:37:56.220Z","hash":"1442988dcab281f4b6fb2549cfed835f510a391e08b4d4f8d66d32ae2daff2af","tsa":{"time":"Oct 22 04:38:21 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Con esto se entiende mejor por qué algunas células logran rejuvenecer y otras se quedan a mitad de camino, algo clave para los tratamientos con células madre. Para una persona de acá, esto significa que las terapias futuras van a depender de controlar muy fino qué pasa dentro de cada célula, no solo de tomar células de cualquier donante. Todavía es un trabajo de laboratorio con pocas personas, así que falta mucho para llevarlo a una clínica.","quienFirma":"bioRxiv (preprint de investigadores internacionales)","confianza":"preprint","consulta":null},"sello":{"hash":"1442988dcab281f4b6fb2549cfed835f510a391e08b4d4f8d66d32ae2daff2af","sello":"cd76b0d08edfbf3429a29f0bce35b76a001eb87f792d95696ed2a210f9f9a900","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573762,"aleatorio":"2bf3d68605c0cf93c7b24bcf7d4852029c1a8fd2dd29c3bf1b3b697bee72ee36","tiempo":"2026-10-22T04:38:00.000Z"},"nist":{"cadena":2,"pulso":1994086,"salida":"7C444532759162AF322A7FA62FB67EDB4DE6FC6E7A6186DDCB567613FCA6BF322E4D0A282AEEE85DC1460DE99BE46FB63B8A2617A10BE805A6618E195E0116AC","tiempo":"2026-10-22T04:37:00.000Z"},"noAntes":"2026-10-22T04:38:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 04:38:21 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Epigenomic heterogeneity and spatial organization during human reprogramming","descripcion":"Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) involves transcriptional and epigenomic remodeling, yet how these changes relate along productive and unsuccessful trajectories remains unclear. We integrated paired single-nucleus measurements of gene expression and chromatin accessibility, gene expression and DNA methylation, or DNA methylation and three-dimensional (3D) genome organization across human fibroblast reprogramming time courses from four individuals, alongside spatial transcriptomics. Starting fibroblasts exhibit DNA methylation heterogeneity within and between individuals, concentrated in broad repressive domains, but donor differences are less apparent in ","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.15.757424v1?rss=1"},"indexado":"2026-10-22T04:37:56.220Z"}}