{"ok":true,"nota":{"id":"5a706ecfccb772c8","slug":"en-pacientes-con-sepsis-la-capacidad-de-disolver-coagulos-se-relaciona-5a706e","titulo":"En pacientes con sepsis, la capacidad de disolver coágulos se relaciona con la gravedad de la falla orgánica","resumen":"Un estudio prospectivo siguió a adultos internados en terapia intensiva con sepsis. Midieron en la cama del paciente la capacidad de disolver coágulos y la compararon con proteínas del plasma y con un puntaje de falla de órganos.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Coupland, L., Self, M., Suryana, E., Law, R., Crispin, P., Medcalf, R., Keragala, C., Frost, S., Rabbolini, D., Moore, P","url":"https://www.medrxiv.org/content/10.64898/2026.10.24.26366401v1?rss=1","imagen":"/hoy/portada/5a706ecfccb772c8","tema":"salud","subtemas":["sepsis","coagulación","terapia intensiva","viscoelastometría","falla orgánica"],"entidades":["terapia intensiva","sepsis"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-27T00:12:40.142Z","hash":"91c7bfa06bd6bba71c7df4c569204a4b80ed36bf86ad27ccbe7af9eb5fd2267d","tsa":{"time":"Oct 27 00:13:42 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Cuando la sangre no logra deshacer los coágulos, el riesgo de complicaciones en la sepsis aumenta, y ahora se puede medir junto a la cama del paciente. Esto puede ayudar a los equipos de terapia intensiva a detectar antes a quienes van peor. Para una familia con un padre internado por una infección grave, significa que hay más herramientas para entender su evolución. Aun así, todavía falta saber si medirlo cambia el destino del paciente.","quienFirma":"medRxiv (preprint de un equipo de terapia intensiva con estudio observacional)","confianza":"preprint","consulta":null},"sello":{"hash":"91c7bfa06bd6bba71c7df4c569204a4b80ed36bf86ad27ccbe7af9eb5fd2267d","sello":"d89cda956deaf738596cf05bfdff492a2a08c95a53c923c5890ee17c11e33fac","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6587632,"aleatorio":"e5f4501cec646e43fc02e0fe1fe4a007971ca7f76b2ee59bcfa3c5f64bf15567","tiempo":"2026-10-27T00:13:00.000Z"},"nist":{"cadena":2,"pulso":2001009,"salida":"D40E14007D6713315067C4542F3D7D0FF922C8FB815DB05FEACE37847166032AAD7591924E5D2623E17D17CD6D56FA07A2A5696B5751C1B97915B1C932BE8E75","tiempo":"2026-10-27T00:12:00.000Z"},"noAntes":"2026-10-27T00:13:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 27 00:13:42 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Fibrinolysis resistance in sepsis assessed by serial beside viscoelastometry is associated with plasma protein profiles and organ-failure severity: a prospective observational study","descripcion":"Background: Fibrinolysis resistance is associated with adverse outcomes in sepsis and can be quantified at the bedside by tissue plasminogen activator-enhanced viscoelastometric testing, using the fibrin-adjusted (FIBA10) clot lysis time (TPA-LT) expressed as the TPA-LT/FIBA10 ratio. In this study of adults admitted to intensive care with sepsis, plasma tissue plasminogen activator activity, plasminogen activator inhibitor-1 activity (PAI-1), plasminogen and a2-antiplasmin were measured serially alongside TPA-LT/FIBA10 and Sequential Organ Failure Assessment (SOFA-2) scores. Whether the bedside TPA-LT/FIBA10 measure of fibrinolysis resistance reflects the underlying plasma fibrinolytic prote","pubDate":"2026-10-26","url":"https://www.medrxiv.org/content/10.64898/2026.10.24.26366401v1?rss=1"},"indexado":"2026-10-27T00:12:40.142Z"}}