{"ok":true,"nota":{"id":"5a617cb096f9f4b9","slug":"cientificos-hallaron-moleculas-de-origen-vegetal-que-podrian-servir-pa-5a617c","titulo":"Científicos hallaron moléculas de origen vegetal que podrían servir para repeler mosquitos","resumen":"Investigadores estudiaron cómo se une un compuesto del olfato del mosquito Anopheles, que transmite la malaria. Analizaron su estructura en laboratorio y buscaron moléculas candidatas en una biblioteca de compuestos volátiles para encontrar nuevos repelentes.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Alonso-Fernandez, J.-R., Stamati, E. C. V., Drakou, C. E., Mazavli, M., Karras, V., Papachristos, D. P., Michaelakis, A.","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.758783v1?rss=1","imagen":"/hoy/portada/5a617cb096f9f4b9","tema":"ciencia","subtemas":["mosquitos","repelentes","malaria","biología molecular","control de vectores"],"entidades":["Anopheles gambiae","bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T16:38:44.280Z","hash":"223835448b4bc0bbaf7fa70870c45bff4c64ef440e1e259c4d1d99f0c5ae0502","tsa":{"time":"Oct 22 16:39:43 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"motor","registro":"hallazgo","porQueImporta":"Hoy los repelentes dependen de muy pocas sustancias, y eso preocupa porque los mosquitos pueden volverse resistentes. Este hallazgo abre una vía distinta para diseñar productos que confundan su olfato. Para alguien que vive en zonas con dengue o paludismo, significa que en unos años podría haber opciones nuevas, aunque todavía estén muy lejos del mostrador. Lo que hoy se midió fue en laboratorio y no en personas ni en el campo.","quienFirma":"bioRxiv (preprint de investigación en biología)","confianza":"preprint","consulta":{"pregunta":"¿Qué tan importante te parece combatir los mosquitos con nuevos repelentes?"}},"sello":{"hash":"223835448b4bc0bbaf7fa70870c45bff4c64ef440e1e259c4d1d99f0c5ae0502","sello":"764ce28fe1480a43971d232ea722af749dda970d7d6f8fcc69259e94e6318e61","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575204,"aleatorio":"ac0f4a6ce509202540c9641abb3a70f7f06eeb36f68a34e1bc3e430369a775da","tiempo":"2026-10-22T16:39:00.000Z"},"nist":{"cadena":2,"pulso":1994801,"salida":"123765DCC46130497358D1E6393BF76FC82D205E2F260DEF171C4887B733C1209F31A193DDD877AB50C2E9F79D0A125A26712AD900F817275AC0E40E5C1C39BC","tiempo":"2026-10-22T16:38:00.000Z"},"noAntes":"2026-10-22T16:39:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 16:39:43 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"AgamOBP4-targeted drug repurposing identifies novel mosquito repellent scaffolds","descripcion":"Odorant-binding proteins (OBPs) play central roles in insect chemoreception and represent attractive molecular targets for the discovery of novel behavior-modifying compounds. We report two crystal structures of Anopheles gambiae OBP4: one complexed with the fluorescent probe N-phenyl-1-naphthylamine and a second containing two indole molecules simultaneously bound within the ligand-binding cavity. Structural comparison revealed two binding subsites accommodating the aromatic moieties of 1-NPN or two indole molecules, while identifying Thr58 and Thr70 as key residues in ligand recognition. A structure-based virtual screening campaign was performed against a volatility-filtered library from D","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.758783v1?rss=1"},"indexado":"2026-10-22T16:38:44.280Z"}}