{"ok":true,"nota":{"id":"5580366041aac322","slug":"la-adversidad-durante-el-embarazo-deja-huellas-en-el-cerebro-de-los-hi-558036","titulo":"La adversidad durante el embarazo deja huellas en el cerebro de los hijos que se ven en la adolescencia","resumen":"Analizaron resonancias cerebrales de adolescentes y la cantidad de adversidades que atravesaron sus madres durante el embarazo. Midieron la integridad de las fibras que conectan zonas ligadas a las emociones a lo largo de los años.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Costello, L. A., Garavan, H., Makowski, C., Ahern, J., Potter, A. S., Reid, B. M., Johnson, M. E., Albaugh, M. D., Dib G","url":"https://www.medrxiv.org/content/10.64898/2026.10.22.26366259v1?rss=1","imagen":"/hoy/portada/5580366041aac322","tema":"salud","subtemas":["salud mental","embarazo","neurodesarrollo","adolescencia","estres prenatal"],"entidades":["adolescentes","madres embarazadas"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T14:15:23.950Z","hash":"6265ecff7e3ae9e17ed2691b02f6a06d455b73abf070fb22d7a42b31166cba22","tsa":{"time":"Oct 26 14:16:10 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Cuantas más situaciones difíciles vivió la madre durante el embarazo, más se asociaron con diferencias en las vías cerebrales que regulan las emociones en la adolescencia, y esas diferencias se vincularon con mayor dificultad para manejarlas. Para una familia de acá, esto indica que el contexto que rodea a una embarazada importa para la salud emocional de sus hijos. Es una señal que pide políticas de apoyo a las madres y no culpas individuales.","quienFirma":"medRxiv (preprint)","confianza":"preprint","consulta":null},"sello":{"hash":"6265ecff7e3ae9e17ed2691b02f6a06d455b73abf070fb22d7a42b31166cba22","sello":"d26581bbabb32f3e2f4912b17957fe5ff84fb4189255759b9b60a16620a181a8","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6586437,"aleatorio":"1aac88eb499d43bdb2eb07e151d5413fa996febc3120c575364c872365467bfd","tiempo":"2026-10-26T14:15:30.000Z"},"nist":{"cadena":2,"pulso":2000412,"salida":"C2419922DC98A3F87F7E26FEDF3D8D702968696059DB8EB9EEBB16C29D6E3E252C7C7913D7A7C8D2519E64F598ADE3A3134A0C4967FCD869639363722BBD3639","tiempo":"2026-10-26T14:15:00.000Z"},"noAntes":"2026-10-26T14:15:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 14:16:10 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Cumulative Prenatal Adversity and Fronto-Limbic White Matter Development Across Adolescence","descripcion":"Importance: The prenatal period is a critical window for intergenerational transmission of adversity, yet the neural substrates through which cumulative prenatal stress becomes biologically embedded in offspring brain development remain poorly understood. White matter microstructure is a candidate mechanism linking prenatal adversity to downstream emotional dysregulation. Objective: To examine associations between cumulative adverse prenatal exposure (APE) burden and fronto-limbic white matter fractional anisotropy (FA) at baseline and across adolescent developmental trajectories, and to test whether white matter FA mediates prenatal APE effects on emotional dysregulation. Design, Setting, a","pubDate":"2026-10-26","url":"https://www.medrxiv.org/content/10.64898/2026.10.22.26366259v1?rss=1"},"indexado":"2026-10-26T14:15:23.950Z"}}