{"ok":true,"nota":{"id":"54a436d6327a5da8","slug":"una-tecnica-con-micropipeta-permite-extraer-celulas-vivas-de-esferas-d-54a436","titulo":"Una técnica con micropipeta permite extraer células vivas de esferas de cultivo 3D","resumen":"Investigadores desarrollaron un sistema manual con micropipeta para extraer grupos de células vivas de la capa externa de esferas tumorales en cultivo 3D. El método busca preservar la estructura y la viabilidad celular.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Pal, V., Maiurov, M., Stellato, M., Hapek, N., Harmati, M., Piccinini, F., Diosdi, A., Horvath, P.","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.760885v1?rss=1","imagen":"/hoy/portada/54a436d6327a5da8","tema":"ciencia","subtemas":["cultivo celular 3d","micromanipulación","tumores","laboratorio","métodos científicos"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T00:00:00.000Z","indexTs":"2026-10-23T12:03:18.526Z","hash":"446146f05d999a881e8614087e2b7814a96075f2f50ac9ecc5c399df1e0e8629","tsa":{"time":"Oct 23 12:03:54 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Estudiar tumores en laboratorio con modelos 3D requiere poder tomar muestras de zonas precisas sin dañarlas. Esta herramienta ofrece una forma más cuidadosa de hacerlo, lo que puede ayudar a entender mejor cómo responden los tumores a los tratamientos. Es una técnica de laboratorio en fase inicial, todavía sin aplicaciones clínicas.","quienFirma":"bioRxiv (preprint; investigación en métodos de cultivo celular 3D)","confianza":"preprint","consulta":null},"sello":{"hash":"446146f05d999a881e8614087e2b7814a96075f2f50ac9ecc5c399df1e0e8629","sello":"5753ab5e3bf1ec357c0c603deb32b1230962802678f4aa63b0181661e680ad54","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6577533,"aleatorio":"c4aba0dd838f5aced1ee3ce73b5a8152f120dc443db083e10a01045483b7000d","tiempo":"2026-10-23T12:03:30.000Z"},"nist":{"cadena":2,"pulso":1995961,"salida":"F41B5D0D554B9AA93D86596521336D547B043E4F52A3C280F10F60EAE511ED1743D3E56670D4E53EB431734AC5B1B8CB5DCF96D1DB26F562D058604979415129","tiempo":"2026-10-23T12:03:00.000Z"},"noAntes":"2026-10-23T12:03:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 12:03:54 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Spheroid surgery: a first-generation micromanipulation platform for extracting viable cell clusters from the outer layers of hydrogel-embedded spheroids","descripcion":"Three-dimensional (3D) cell culture systems have gained attention as in vitro models capable of reproducing the tissue-like architecture, spatial organization, and physiological morphology of in vivo tumors. Their ability to mimic native cell-cell and cell-matrix interactions has positioned 3D cell cultures as powerful models for studying tumor biology and drug responses. However, methods for the localized extraction of viable cells remain limited, as existing approaches often disrupt the original 3D structure, limit access to defined regions, or compromise cell viability, restricting the biological insight that can be achieved. We present a manual, micropipette-based manipulation system des","pubDate":"2026-10-23","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.760885v1?rss=1"},"indexado":"2026-10-23T12:03:18.526Z"}}