{"ok":true,"nota":{"id":"52c6466ed3a8ed0e","slug":"patrones-de-textura-en-biopsias-del-tejido-de-prostata-podrian-anticip-52c646","titulo":"Patrones de textura en biopsias del tejido de próstata podrían anticipar una recaída tras la cirugía","resumen":"Analizaron imágenes de tejido extraído en cirugías de próstata combinando tinciones comunes con marcadores inmunes. Intentaron predecir cuándo el cáncer podría volver, en un grupo muy pequeño de 15 pacientes.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Oderinde, O. M., Chimmula, R. R., Nair, V., Holmes, J., Bahler, C.","url":"https://www.medrxiv.org/content/10.64898/2026.10.23.26366338v1?rss=1","imagen":"/hoy/portada/52c6466ed3a8ed0e","tema":"salud","subtemas":["cáncer de próstata","patología digital","recaída","prostatectomía","pronóstico"],"entidades":["medRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T15:36:30.917Z","hash":"0f92847aa298ee1bbd8c9e5aff0abf38c3ace13a2c370a57bbe3d5c967b73c77","tsa":{"time":"Oct 26 15:37:03 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Después de sacar la próstata, algunos hombres vuelven a tener aumento del PSA y no hay forma sencilla de saber quién tendrá una recaída. Este trabajo explora si la textura del tejido aporta una pista extra a los datos clínicos conocidos. Con solo 15 pacientes, es apenas una hipótesis, pero indica hacia dónde mirar para ajustar los controles de cada hombre. El límite serio es el tamaño de la muestra: sin validar con cientos de casos, no sirve para decidir nada.","quienFirma":"medRxiv (preprint; estudio retrospectivo exploratorio)","confianza":"preprint","consulta":null},"sello":{"hash":"0f92847aa298ee1bbd8c9e5aff0abf38c3ace13a2c370a57bbe3d5c967b73c77","sello":"35244849f7165eeb80843f983bf633a0c7781ff5baee773875daceddff0397f0","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6586600,"aleatorio":"b890a385cf92974374211108b695f20f26b378db0776577c156830220ff127b8","tiempo":"2026-10-26T15:37:00.000Z"},"nist":{"cadena":2,"pulso":2000493,"salida":"561AB66CD420DAD021A79CE9030A7B3512C7392399F0542651AB8883F6508DDB391A1A35AF6893D1E04E4FDDE2374CB221AE98089FAC353C5E66C30F2D8BF390","tiempo":"2026-10-26T15:36:00.000Z"},"noAntes":"2026-10-26T15:37:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 15:37:03 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Pathomic Texture Composites from H&E, and Immunohistochemistry of Prostatectomy Specimens for Exploratory Modeling of Time to Biochemical Recurrence","descripcion":"Background: Pathomic analysis, the extraction of quantitative features from digitized histology, can capture tissue patterns that may complement conventional prognostic factors. We explored whether stain-specific texture composites derived from hematoxylin and eosin (H&E), CD8, and CD163 immunohistochemistry add information to models of time to biochemical recurrence (BCR) after radical prostatectomy. Methods: This retrospective exploratory study included 15 patients with digitized prostatectomy specimens and linked clinicopathologic data. Handcrafted pathomic features were extracted from image tiles with PyRadiomics, averaged within patients, and standardized. Three stain-specific, equal-we","pubDate":"2026-10-26","url":"https://www.medrxiv.org/content/10.64898/2026.10.23.26366338v1?rss=1"},"indexado":"2026-10-26T15:36:30.917Z"}}