{"ok":true,"nota":{"id":"5272027c0214ab5e","slug":"un-estudio-con-miles-de-chicos-detecta-dos-tipos-biologicos-distintos--527202","titulo":"Un estudio con miles de chicos detecta dos tipos biológicos distintos de TDAH","resumen":"Analizaron resonancias cerebrales de más de 14.000 niños de China y Estados Unidos, con y sin TDAH. Usaron modelos estadísticos para comparar la forma de la corteza cerebral de cada uno con lo esperado para su edad.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Bu, X., Sun, L., Fu, Z., Zhao, Y., Zheng, X., Zhang, K., Liang, X., Cui, Z., Gao, J.-H., Gong, G., Huang, R., Li, S., Lu","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.760978v1?rss=1","imagen":"/hoy/portada/5272027c0214ab5e","tema":"salud","subtemas":["tdah","neuroimagen infantil","resonancia magnética","diagnóstico psiquiátrico","medicina personalizada"],"entidades":["bioRxiv","China","Estados Unidos"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T00:00:00.000Z","indexTs":"2026-10-24T07:11:26.444Z","hash":"07e43c966d15c535397a4e7740bacefbfa8f4b5d07e33376935201aa73546df1","tsa":{"time":"Oct 24 07:11:51 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"motor","registro":"hallazgo","porQueImporta":"Encontraron dos grupos de chicos con TDAH con patrones cerebrales diferentes: uno con la corteza más delgada en amplias zonas y otro con un patrón opuesto. Esto sugiere que el TDAH no es una sola cosa y que los tratamientos podrían funcionar distinto según el tipo. Para una familia argentina que espera años por un diagnóstico claro, abre la puerta a dejar de tratar a todos igual. Igual, son resultados de un preprint y todavía no se traducen en un test clínico.","quienFirma":"bioRxiv (preprint; institución principal no identificada en el texto)","confianza":"preprint","consulta":{"pregunta":"¿Cree que el TDAH debería diagnosticarse con estudios cerebrales?"}},"sello":{"hash":"07e43c966d15c535397a4e7740bacefbfa8f4b5d07e33376935201aa73546df1","sello":"b29e850b3eb0bc35c04eef6c08b469232c58fd73ca05ff99975b244ffd2a38c1","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6579829,"aleatorio":"d48f9fe52bf743995742697fd085adfb6f40e41f7233e298366d75e9448602af","tiempo":"2026-10-24T07:11:30.000Z"},"nist":{"cadena":2,"pulso":1997108,"salida":"3CBF91F80A49092AFEC55B0059D389B43E7122B11EFD9D5DC51BB675C57811789BC8E4E0B74E1F88160AC449925D7B2B631BEFDB3101327F45B992F1A31F1D08","tiempo":"2026-10-24T07:11:00.000Z"},"noAntes":"2026-10-24T07:11:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 24 07:11:51 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Pediatric brain charts reveal ADHD biotypes with distinct developmental, molecular, and therapeutic profiles","descripcion":"Attention-deficit/hyperactivity disorder (ADHD) exhibits profound clinical heterogeneity; however, its underlying neurobiological substrates remain unclear. Here, leveraging large - scale structural magnetic resonance imaging data from 12,663 typically developing children and 1,699 children with ADHD across Chinese and United States cohorts, we construct population specific pediatric brain charts via hierarchical Bayesian normative modeling to quantify individual deviations in cortical morphology. Data-driven clustering identifies two robust, cross - ethnically replicable ADHD biotypes: an infra - normal biotype characterized by widespread cortical thinning and a supra - normal biotype marke","pubDate":"2026-10-23","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.760978v1?rss=1"},"indexado":"2026-10-24T07:11:26.444Z"}}