{"ok":true,"nota":{"id":"50e15cd2ac50970b","slug":"una-proteina-alterada-de-la-enfermedad-sca17-cambia-mucho-mas-que-la-t-50e15c","titulo":"Una proteína alterada de la enfermedad SCA17 cambia mucho más que la transcripción de los genes","resumen":"Investigadores usaron moscas de la fruta modificadas para expresar la versión normal o la versión con la mutación de la proteína TBP, en neuronas y en músculo. Compararon miles de proteínas, modificaciones químicas y ARN. Encontraron efectos compartidos sobre ribosomas, mitocondrias y la inmunidad innata.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Prifti, M. V., Richardson, K., Hussein, F. H., Kula, T., Stephan, A., Wang, Y.-D., Wang, W., High, A. A., Poudel, S., De","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760399v1?rss=1","imagen":"/hoy/portada/50e15cd2ac50970b","tema":"ciencia","subtemas":["genetica","enfermedades neurodegenerativas","ataxia","proteomica","drosophila"],"entidades":["SCA17","TBP","Drosophila"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T22:39:37.287Z","hash":"42ba2ff741d8c63219b3c80cb562f3f04f710d3543a7df81a88de78fac379d97","tsa":{"time":"Oct 21 22:40:35 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La mutación que causa la ataxia SCA17 altera la forma en que se fabrican proteínas en las células, no solo la forma en que se leen los genes. Eso amplía el mapa de qué falla en la enfermedad y, con eso, dónde podrían buscarse futuros tratamientos. Todavía son resultados en moscas y en un preprint sin revisión, así que falta mucho para cualquier aplicación en personas.","quienFirma":"Institución no identificada en el texto disponible","confianza":"preprint","consulta":null},"sello":{"hash":"42ba2ff741d8c63219b3c80cb562f3f04f710d3543a7df81a88de78fac379d97","sello":"c3f0a60d37914924662be1ebe5c989253ceb4c0187b8cc9fa122b336f6f8c796","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573046,"aleatorio":"f71b3db032f12c8ae2d90f38aa37ddc03a4bd072f8a3317f2962e831c62e695d","tiempo":"2026-10-21T22:40:00.000Z"},"nist":{"cadena":2,"pulso":1993728,"salida":"DBB029F00A75EEAA9AF69BB0B3207AD12D5A4EDD2136CB35D25CB332980962472F1AFBB0B247EB7DF6BE52045BC8A63F1D14E2719075ECD2BA39DE673005A0E1","tiempo":"2026-10-21T22:39:00.000Z"},"noAntes":"2026-10-21T22:40:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 22:40:35 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Polyglutamine-expanded TBP rewires neuronal and muscle proteomes beyond transcription in a Drosophila model of SCA17","descripcion":"Spinocerebellar ataxia type 17 (SCA17) is an age-related neurodegenerative disorder caused by polyglutamine expansion in the TATA-binding protein (TBP). TBP is a core transcription factor, but pathogenic polyglutamine expansion likely rewires cellular programs beyond transcription. Here, we utilized Drosophila strains that express wild-type (WT) or pathogenic (SCA17) TBP in neurons or skeletal muscle, which we analyzed vs. controls via TMT mass spectrometry, profiling of eight post-translational modifications, and RNA-seq. Shared TBP-WT and TBP-SCA17 responses predominated, impacting ribosomes and mitochondria while repressing innate immunity. Disease-specific effects were narrower and tissu","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760399v1?rss=1"},"indexado":"2026-10-21T22:39:37.287Z"}}