{"ok":true,"nota":{"id":"4f92de8b601d761c","slug":"tomar-alcohol-durante-el-embarazo-afectaria-de-forma-distinta-a-los-be-4f92de","titulo":"Tomar alcohol durante el embarazo afectaría de forma distinta a los bebés según la genética de la madre, en un","resumen":"Analizaron datos de unas 68 mil madres e hijos de Noruega para ver si el consumo de alcohol en el embarazo se relacionaba con el desarrollo infantil. Consideraron variantes genéticas que afectan cómo el cuerpo procesa el alcohol. Evaluaron si esas variantes modificaban el efecto.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Hughes, A. M., Slaney, C., Tilling, K., Madley-Dowd, P., Havdahl, A., Davey Smith, G.","url":"https://www.medrxiv.org/content/10.64898/2026.10.20.26365709v1?rss=1","imagen":"/hoy/portada/4f92de8b601d761c","tema":"salud","subtemas":["alcohol en el embarazo","desarrollo infantil","genética","salud materna","epidemiología"],"entidades":["medRxiv","Noruega","MoBa","Japón"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T23:19:43.636Z","hash":"26667218c2e27c1b4b950196e9e86b085d1e7f04f2a71487780644ec873d1851","tsa":{"time":"Oct 22 23:20:46 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La recomendación de no tomar alcohol en el embarazo ya es clara, y este trabajo no la cambia. Lo que muestra es que la genética puede modificar cuánto daño hace, un dato que viene de estudios en Japón y que ahora se pone a prueba en otra población. Para una embarazada, la conclusión práctica sigue siendo la misma: cero alcohol, sin importar qué genes tenga.","quienFirma":"Preprint en medRxiv (Norwegian Mother, Father and Child Cohort Study, MoBa)","confianza":"preprint","consulta":null},"sello":{"hash":"26667218c2e27c1b4b950196e9e86b085d1e7f04f2a71487780644ec873d1851","sello":"0a926ba2ca91852955381c7aef9034b8cd239e2f0a739f02f654f6fcc21d263b","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6576007,"aleatorio":"95dbaf32f50651e333ceec71d41e8fb48fb5366fda7d20abcbc7ea91ece96f50","tiempo":"2026-10-22T23:20:30.000Z"},"nist":{"cadena":2,"pulso":1995203,"salida":"8A13BF41CC085A093FFEA64CBB7EB887732A2613A6D9655D0453147066A38EB79E9EC218F3D2AC07553BF1FD20E0E18DC3AD27C19DD5DB9E691AB8B8E2BD47D3","tiempo":"2026-10-22T23:20:00.000Z"},"noAntes":"2026-10-22T23:20:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 23:20:46 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Are effects of drinking in pregnancy modified by ADH1B and ALDH2 genotype? A longitudinal analysis in the Norwegian Mother, Father and Child Cohort Study (MoBa)","descripcion":"Background Recent evidence from a Japanese study suggests that adverse impacts of prenatal alcohol exposure (PAE) on child development are substantially modified by maternal genotype for rs671, a variant in the aldehyde dehydrogenase 2 gene (ALDH2) which impacts alcohol metabolism. This specific null variant is largely restricted to East Asian populations. Whether variants impacting alcohol metabolism in other ancestral groups could have similar effects is unclear. Methods Using data from the Norwegian Mother, Father, and Child Cohort Study (N=68,325 mother-child duos, data collected 2000-2011) we explored whether maternal drinking in early (1-15 weeks) or mid-pregnancy (13-30 weeks) was ass","pubDate":"2026-10-22","url":"https://www.medrxiv.org/content/10.64898/2026.10.20.26365709v1?rss=1"},"indexado":"2026-10-22T23:19:43.636Z"}}