{"ok":true,"nota":{"id":"4d1a7ba8ffc7cc90","slug":"combinaciones-de-anticuerpos-de-la-madre-podrian-anticipar-riesgo-de-a-4d1a7b","titulo":"Combinaciones de anticuerpos de la madre podrían anticipar riesgo de autismo en el hijo","resumen":"Revisaron muestras de sangre de madres de chicos con autismo y de otras de control. Buscaron combinaciones de anticuerpos asociadas al diagnóstico y probaron el hallazgo en una cohorte externa.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Wassman, E. R., Martin, M., Schauer, J., Van de Water, J. A., Paul, M. S.","url":"https://www.medrxiv.org/content/10.64898/2026.10.23.26366364v1?rss=1","imagen":"/hoy/portada/4d1a7ba8ffc7cc90","tema":"salud","subtemas":["autismo","anticuerpos maternos","embarazo","diagnostico temprano"],"entidades":["medRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T23:22:05.517Z","hash":"dd89fe29887712bd9029b2969cd888f8f504b1d56cc17a834f62730b3bd1f2f9","tsa":{"time":"Oct 26 23:22:42 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"motor","registro":"hallazgo","porQueImporta":"Se identificó una pista biológica que podría usarse como test de riesgo en embarazadas con más probabilidad de tener un hijo con autismo. Para una familia, esto a futuro podría significar detección más temprana, pero todavía no es un examen disponible ni un diagnóstico. El trabajo es preliminar, se basó en un número limitado de muestras y necesita confirmarse en poblaciones más amplias antes de usarse.","quienFirma":"Universidad no especificada en el preprint (investigación sobre autoanticuerpos maternos y autismo)","confianza":"preprint","consulta":{"pregunta":"¿Te gustaría que existiera un test de riesgo en el embarazo?"}},"sello":{"hash":"dd89fe29887712bd9029b2969cd888f8f504b1d56cc17a834f62730b3bd1f2f9","sello":"6cf5c724a15d1fc540a2af8f9308f085233b7e00843bc80879f3f9e1889393f4","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6587531,"aleatorio":"fe6a0d1e32f33530ee3865ce898a933a679d836c030556cafcf9f7f9e03e9c1f","tiempo":"2026-10-26T23:22:30.000Z"},"nist":{"cadena":2,"pulso":2000959,"salida":"38EFC3652F96D1340187DD7D5B32A840F878CD33000D34F2E88A92400DF1FC86B990B57549F5A1FBF1EAABF05D417E628C2ED1C646A08A636235AA53F1954B2D","tiempo":"2026-10-26T23:22:00.000Z"},"noAntes":"2026-10-26T23:22:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 23:22:42 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Maternal Autoantibody Combinations as Predictors of Autism Risk: Retrospective Discovery and External Validation in a Prospective Cohort at Increased Risk","descripcion":"Background/Objectives: Maternal Autoantibody-Related Autism (MARA) is a recently defined subset of autism characterized by specific combinations of maternal autoantibodies which cross the placenta and bind neurodevelopmentally critical target proteins. A clinical multi-ELISA MARA assay was recently rigorously analytically validated. The primary objective of this study was to assess the potential performance of this MARA autoantibody assay for predicting autism risk in high-risk populations. Secondary objectives were to establish the significant MARA autoantibody combinations and verify clinical discrimination in an external cohort. Methods: Bio-banked plasma samples from mothers of 420 autis","pubDate":"2026-10-26","url":"https://www.medrxiv.org/content/10.64898/2026.10.23.26366364v1?rss=1"},"indexado":"2026-10-26T23:22:05.517Z"}}