{"ok":true,"nota":{"id":"49b53e40ca51956f","slug":"la-radiacion-hace-que-el-tumor-cerebral-recaido-genere-una-cubierta-qu-49b53e","titulo":"La radiación hace que el tumor cerebral recaído genere una cubierta que frena al sistema inmune","resumen":"Investigadores encontraron que, tras la radiación y en las recaídas, el glioblastoma aumenta la producción de colágeno I y III. Ese aumento se asoció con menor supervivencia de los pacientes y con más células que suprimen la respuesta inmune en el tumor.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Iwaloye, O., Barr, L., Takei, J., Tsuzuki, S., Kumar, H., Osuka, S.","url":"https://www.biorxiv.org/content/10.64898/2026.10.14.759139v1?rss=1","imagen":"/hoy/portada/49b53e40ca51956f","tema":"salud","subtemas":["glioblastoma","radioterapia","recaida-tumoral","inmunosupresion","colageno"],"entidades":["COL I&III","TGF-beta"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-21T05:32:19.019Z","hash":"8d51fc12193931c38af83520771c8ee8716b828e7f8c04396290c3ee455510cd","tsa":{"time":"Oct 21 05:32:48 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"El glioblastoma es uno de los tumores cerebrales más agresivos, y las recaídas son el momento en que más cuesta tratarlo. Este trabajo sugiere que el propio tumor construye un entorno que apaga las defensas del cuerpo, y que ese cambio empeora el pronóstico. Para un paciente o familia de acá, indica un posible blanco nuevo para tratamientos que se combinen con la radioterapia. Es un hallazgo con datos de pacientes y de modelos, pero aún no hay una terapia que lo use.","quienFirma":"bioRxiv (preprint; institución principal no identificada en el extracto)","confianza":"preprint","consulta":null},"sello":{"hash":"8d51fc12193931c38af83520771c8ee8716b828e7f8c04396290c3ee455510cd","sello":"c936cd4ecd65d72b20b9f6dde188b34d165f4031af582e601056487052d2eb46","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6570990,"aleatorio":"197cfefbaae84a11019800f736fb3d999fc9deaffc98cec0c35453a67bb3b551","tiempo":"2026-10-21T05:32:00.000Z"},"nist":{"cadena":2,"pulso":1992700,"salida":"779B9C05152B4CBD1C0DC8A789A98414BB1FB7FC9BCD4C986DB35B0B6DFFACF69BCA3C8A248326F1AFCD58751A3730795B71A1BBC058A265C3BB6F3B3B74127C","tiempo":"2026-10-21T05:31:00.000Z"},"noAntes":"2026-10-21T05:32:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 05:32:48 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Radiation-Induced Collagen I&III Accumulation Drives Immunosuppressive Evolution in Recurrent Glioblastoma","descripcion":"Glioblastoma (GBM) recurrence is accompanied by extracellular matrix remodeling, but the signaling mechanisms linking matrix changes to immune suppression remain unclear. Integrating human transcriptomic datasets with our models developed through repeated irradiation to investigate recurrence-associated tumor evolution, we found increased COL I&III expression at recurrence and after irradiation, with higher expression associated with shorter patient survival. Spatial transcriptomics revealed enrichment of immunosuppressive cell signatures and TGF-{beta} signaling programs in COL I&III-rich human GBM regions. Tumor-cell COL I&III knockout reduced regulatory T cell and monocytic myeloid-derive","pubDate":"2026-10-20","url":"https://www.biorxiv.org/content/10.64898/2026.10.14.759139v1?rss=1"},"indexado":"2026-10-21T05:32:19.019Z"}}