{"ok":true,"nota":{"id":"419e310a00b047ae","slug":"un-analisis-de-sangre-detecta-cambios-en-el-adn-vinculados-al-alzheime-419e31","titulo":"Un análisis de sangre detecta cambios en el ADN vinculados al Alzheimer","resumen":"Investigadores estudiaron el ADN que circula en la sangre de personas con y sin Alzheimer y encontraron cambios epigenéticos parecidos a los que aparecen en el cerebro. Compararon muestras de participantes de un proyecto de envejecimiento en Estados Unidos.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Cui, X., Beadell, A. V., Tasaki, S., Capuano, A. W., Zhang, Z., Gao, L., Chiu, B. C.- H., He, C., Bennett, D. A., Arvani","url":"https://www.medrxiv.org/content/10.64898/2026.10.24.26366278v1?rss=1","imagen":"/hoy/portada/419e310a00b047ae","tema":"salud","subtemas":["alzheimer","epigenética","diagnóstico temprano","adn en sangre","demencia"],"entidades":["Rush Memory and Aging Project","Estados Unidos"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T21:44:45.754Z","hash":"4db0bf73536239c48e86ef4303748c3e7351868154778ac61d7a51ef56a568b3","tsa":{"time":"Oct 26 21:45:27 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hoy diagnosticar el Alzheimer suele exigir estudios caros o invasivos, y muchas familias llegan tarde. Si una muestra de sangre pudiera revelar señales vinculadas al cerebro, el diagnóstico sería más accesible y temprano. Esto no quiere decir que haya un test listo para usar: el estudio es exploratorio y necesita confirmarse con más personas. Aun así, marca una dirección posible para cuidar la memoria antes de que los síntomas sean evidentes.","quienFirma":"Rush University (EE. UU.)","confianza":"preprint","consulta":null},"sello":{"hash":"4db0bf73536239c48e86ef4303748c3e7351868154778ac61d7a51ef56a568b3","sello":"b2030e18510e15903b28d96e4a1f986345cec26de3479cc2b2962133312ccdbe","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6587336,"aleatorio":"7f09892dc40bc182e2fd089c9cd7da6d4bf0ce04b004bf22db591df3c5e9aa66","tiempo":"2026-10-26T21:45:00.000Z"},"nist":{"cadena":2,"pulso":2000861,"salida":"7270D97C2D57F9CB7EB7B095A08C5FEB9B89AB79EC9A8CA95295DF433D69A435C33F40AA23444ADF25BC5940158B01E8B7275199BCC1D89A41E5D4F68D952C8B","tiempo":"2026-10-26T21:44:00.000Z"},"noAntes":"2026-10-26T21:45:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 21:45:27 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Ultra-sensitive Mapping of Cell-free DNA-derived Methylomes Reveals Brain-specific Epigenetic Alterations Implicated in Alzheimer Disease","descripcion":"DNA cytosine modifications play a crucial role in gene regulation that underlies the pathogenesis of complex diseases such as Alzheimer disease (AD). Using LABS (Linear Amplification-based Bisulfite Sequencing), an ultra-sensitive linear amplification-based low-input whole-genome methylation profiling method, we demonstrated the feasibility of detecting altered methylation features in serum-derived cell-free DNA (cfDNA) between a set of age- and sex-matched pathologically-defined participants with AD and non-AD controls, from the Rush Memory and Aging Project. These blood methylation changes were further linked to brain-specific epigenetic alterations implicated in AD. These findings support","pubDate":"2026-10-26","url":"https://www.medrxiv.org/content/10.64898/2026.10.24.26366278v1?rss=1"},"indexado":"2026-10-26T21:44:45.754Z"}}