{"ok":true,"nota":{"id":"41003f6df3df04aa","slug":"desarrollan-una-molecula-que-cruza-la-barrera-del-cerebro-y-reduce-la--41003f","titulo":"Desarrollan una molécula que cruza la barrera del cerebro y reduce la inflamación en ratones con Alzheimer","resumen":"Tras analizar una biblioteca de 4.200 millones de compuestos, identificaron una molécula llamada DELC2 que bloquea la proteína CHI3L1 y llega al cerebro. En cultivos de células gliales redujo la inflamación y mejoró la captación de beta amiloide.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Upadhyay, S., Zhang, L., Kaur, B., Calvo-Barreiro, L., Teplova, M., Gabr, M.","url":"https://www.biorxiv.org/content/10.64898/2026.10.15.759511v1?rss=1","imagen":"/hoy/portada/41003f6df3df04aa","tema":"salud","subtemas":["alzheimer","neuroinflamación","fármacos","barrera hematoencefálica"],"entidades":["bioRxiv","CHI3L1","DELC2"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-22T04:37:56.220Z","hash":"110b9c644ab9ed18f0ebeded009b8044ad8ac4a1a89d9a67b2a3a563908cd2a6","tsa":{"time":"Oct 22 04:38:22 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"motor","registro":"hallazgo","porQueImporta":"El Alzheimer tiene una parte inflamatoria que hoy casi no se puede frenar, y este hallazgo apunta a una vía nueva que podría explorarse. Para una persona de acá, con familiares que envejecen y un sistema de salud con listas de espera, cualquier opción que llegue por pastilla y no por inyección sería una diferencia enorme. Pero todo lo mostrado es en células y en animales; de la molécula al consultorio hay años de pruebas y muchas posibilidades de que no funcione.","quienFirma":"bioRxiv (preprint de investigadores internacionales)","confianza":"preprint","consulta":{"pregunta":"¿Te preocupa más el Alzheimer o la inflamación en general?"}},"sello":{"hash":"110b9c644ab9ed18f0ebeded009b8044ad8ac4a1a89d9a67b2a3a563908cd2a6","sello":"71dc28039115523b7b4df0879fabe465632652dde2155fe3ff0403883d407914","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573762,"aleatorio":"2bf3d68605c0cf93c7b24bcf7d4852029c1a8fd2dd29c3bf1b3b697bee72ee36","tiempo":"2026-10-22T04:38:00.000Z"},"nist":{"cadena":2,"pulso":1994086,"salida":"7C444532759162AF322A7FA62FB67EDB4DE6FC6E7A6186DDCB567613FCA6BF322E4D0A282AEEE85DC1460DE99BE46FB63B8A2617A10BE805A6618E195E0116AC","tiempo":"2026-10-22T04:37:00.000Z"},"noAntes":"2026-10-22T04:38:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 04:38:22 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Discovery of a brain-penetrant CHI3L1 inhibitor as an oral modulator of neuroinflammation in Alzheimers disease","descripcion":"Chitinase-3-like protein 1 (CHI3L1) is elevated in Alzheimers disease (AD), but its role in glial dysfunction and therapeutic tractability remain unclear. Here, screening a 4.2-billion-compound DNA-encoded library identified DELC2, a brain-penetrant CHI3L1 modulator. Biophysical and crystallographic studies showed that DELC2 binds the CHI3L1 glycan-recognition groove within an aromatic-hydrophobic pocket centered on Trp99 and Trp352. DELC2 inhibited CHI3L1-RAGE association, suppressed CHI3L1-induced inflammatory signaling, reduced Gal-3-positive microglia, and restored amyloid-{beta} uptake in glial cultures. In human cerebrospinal fluid, CHI3L1 was elevated in AD and correlated with astrocy","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.15.759511v1?rss=1"},"indexado":"2026-10-22T04:37:56.220Z"}}