{"ok":true,"nota":{"id":"4021b2cbc9eab9fd","slug":"una-variante-genetica-cambia-como-se-mide-la-inflamacion-cerebral-en-f-4021b2","titulo":"Una variante genética cambia cómo se mide la inflamación cerebral en fibromialgia, fatiga crónica y esclerosis","resumen":"Investigadores genotiparon a 86 participantes para una variante genética que altera la lectura de un marcador de inflamación cerebral por PET. Compararon la frecuencia de esa variante entre personas con fibromialgia, síndrome de fatiga crónica, esclerosis múltiple y controles.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Jones, C. L., Younger, J. W.","url":"https://www.medrxiv.org/content/10.64898/2026.10.19.26365953v1?rss=1","imagen":"/hoy/portada/4021b2cbc9eab9fd","tema":"ciencia","subtemas":["inflamación cerebral","fibromialgia","esclerosis múltiple","genética","pet"],"entidades":["medRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T22:39:37.287Z","hash":"8ea30d99413fd0ef2bc47261d4a0f9ba8a3dde5f7137faa60d61782feeac50cb","tsa":{"time":"Oct 21 22:40:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Encontraron que ciertas variantes genéticas, que hacen que el estudio por imágenes vea menos inflamación, aparecen con más frecuencia en estas enfermedades. Para alguien que vive con fibromialgia o fatiga crónica, esto sugiere que las imágenes cerebrales de la inflamación podrían estar subestimadas según la genética de cada persona. Con una muestra tan chica, es una pista para investigar, no una conclusión sobre estas enfermedades.","quienFirma":"Universidad no identificada en el resumen (preprint en medRxiv)","confianza":"preprint","consulta":null},"sello":{"hash":"8ea30d99413fd0ef2bc47261d4a0f9ba8a3dde5f7137faa60d61782feeac50cb","sello":"84a1ea04fdf0530ad8b287138f2262b208cc79ddf06612429343632c5bab9ea5","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573046,"aleatorio":"f71b3db032f12c8ae2d90f38aa37ddc03a4bd072f8a3317f2962e831c62e695d","tiempo":"2026-10-21T22:40:00.000Z"},"nist":{"cadena":2,"pulso":1993728,"salida":"DBB029F00A75EEAA9AF69BB0B3207AD12D5A4EDD2136CB35D25CB332980962472F1AFBB0B247EB7DF6BE52045BC8A63F1D14E2719075ECD2BA39DE673005A0E1","tiempo":"2026-10-21T22:39:00.000Z"},"noAntes":"2026-10-21T22:40:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 22:40:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Fibromyalgia, Chronic Fatigue Syndrome, and Multiple Sclerosis are associated with lower translocator protein binding affinity genotypes","descripcion":"Introduction: Neuroinflammation is a known pathophysiologic mechanism in multiple sclerosis and a proposed mechanism in fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Positron Emission Tomography (PET) imaging of the translocator protein (TSPO) has been widely used to measure neuroinflammation, though second-generation ligands are highly sensitive to a single nucleotide polymorphism, rs6971, resulting in high, mixed, and low affinity binders. It is unknown whether this polymorphism is associated with neuroinflammatory disorders. Materials and Methods: Eighty-six total participant genotypes for TSPO binding affinity were identified through Sanger sequencing (30 ","pubDate":"2026-10-21","url":"https://www.medrxiv.org/content/10.64898/2026.10.19.26365953v1?rss=1"},"indexado":"2026-10-21T22:39:37.287Z"}}