{"ok":true,"nota":{"id":"3f8723133b38666b","slug":"un-estudio-con-427-donantes-muestra-que-celulas-cambian-en-el-cerebro--3f8723","titulo":"Un estudio con 427 donantes muestra qué células cambian en el cerebro con Alzheimer","resumen":"Investigadores analizaron más de dos millones de núcleos celulares de 427 personas fallecidas, con y sin Alzheimer, para buscar patrones de cambio que se repitan. Identificaron alteraciones en ciertas neuronas y en células que ayudan a la comunicación entre neuronas.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Vilkaite, G., Volcov, E., An, L., Xiao, Y., Hristovska, I., Rosat Consiglio, C., Pichet-Binette, A., Mattsson-Carlgren, ","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.759610v1?rss=1","imagen":"/hoy/portada/3f8723133b38666b","tema":"salud","subtemas":["alzheimer","neurociencia","celulas cerebrales","investigacion biomedica","enfermedades neurodegenerativas"],"entidades":["ROSMAP","Alzheimer","Rush University"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T00:00:00.000Z","indexTs":"2026-10-23T18:12:31.737Z","hash":"6fb2fc59c6024b7549b26ebf6c812875fec857d44619aee059faf29fe8d80e41","tsa":{"time":"Oct 23 18:13:29 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hasta ahora, muchos hallazgos sobre el Alzheimer eran aislados y difíciles de reproducir. Este trabajo busca un mapa más completo de cómo responden distintas células juntas, algo clave para pensar tratamientos futuros. Para una familia argentina que convive con la enfermedad, todavía no cambia nada en el día a día. Pero marca un camino: entender el problema como un conjunto y no como piezas sueltas. Es un paso de laboratorio, no una solución cercana.","quienFirma":"ROSMAP (Rush University y otras instituciones de Estados Unidos)","confianza":"preprint","consulta":null},"sello":{"hash":"6fb2fc59c6024b7549b26ebf6c812875fec857d44619aee059faf29fe8d80e41","sello":"19143a0e78b62c3bfccb883d79d46344b1a894ab515f902cf1e7a6b3af827e39","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6578272,"aleatorio":"e504aca3fcd7243fddbec8b88f1c51dc96cb1f827ccda23c013f3b302f3c69ab","tiempo":"2026-10-23T18:13:00.000Z"},"nist":{"cadena":2,"pulso":1996329,"salida":"880EE1B503674E57D0E81D7CEC0FFDBB3A3BB5CD5A62E05BB575BBCB9E2DB29F611799CDCF1B120D62E8DF3A39AE0D1B9935A0A198FC708C5974107E51CFF0C4","tiempo":"2026-10-23T18:12:00.000Z"},"noAntes":"2026-10-23T18:13:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 18:13:29 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"A coordinated and reproducible multicellular response to AD pathology","descripcion":"While single-cell measurements of the Alzheimer's disease (AD) brain allow investigation of vulnerable cells in unprecedented depth, reported findings are heterogeneous, mostly descriptive and often ignore interdependence of cellular responses. Operationalization of these findings requires a multi-cellular model of AD that is robust and reproducible. Here, we utilize a coordinated multicellular community approach across 2.3 million nuclei from 427 ROSMAP donors to identify robust multicellular axes associated with AD pathology and sex. The AD signature comprised profound alteration to RORB-GABRG excitatory neurons and disrupted oligodendrocyte precursor cell signaling. A separate set of AD-r","pubDate":"2026-10-23","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.759610v1?rss=1"},"indexado":"2026-10-23T18:12:31.737Z"}}