{"ok":true,"nota":{"id":"3c2f21a71f379afa","slug":"un-programa-automatico-mide-el-orden-de-las-celulas-de-la-cornea-de-do-3c2f21","titulo":"Un programa automático mide el orden de las células de la córnea de donantes para evaluar trasplantes","resumen":"Investigadores crearon Cornealia, un sistema automático que analiza cómo se organizan entre sí las células del endotelio corneal. Lo probaron en células en cultivo, donde el orden disminuye con los pasajes y se conserva con ciertos factores de crecimiento.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Rostami, M., Asim, S., Steele, M., Kyauk, D. S., Moul, L., Haarman, S., Richard, A., Peh, G., Moore, D., Rizwan, M., Meh","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760745v1?rss=1","imagen":"/hoy/portada/3c2f21a71f379afa","tema":"salud","subtemas":["cornea","trasplantes","endotelio","analisis-automatico","bancos-de-tejidos"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-27T00:12:40.142Z","hash":"ba8fc6942ab79fef31a8f0eafe5a896427dca10e80f7569341bcec2c4b8179e3","tsa":{"time":"Oct 27 00:13:42 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hoy los bancos de córneas miran sobre todo células individuales, y este trabajo propone medir cómo se ordena la capa completa, que es lo que sostiene la córnea. Si esa medición se valida, podría ayudar a decidir qué tejido sirve para un trasplante, algo que afecta directamente a quien espera ver mejor. Pero por ahora la prueba es en laboratorio, con células en cultivo, y falta confirmar qué pasa en tejido de donantes reales.","quienFirma":"Universidad (preprint de bioRxiv; institución principal no visible en el texto recibido)","confianza":"preprint","consulta":null},"sello":{"hash":"ba8fc6942ab79fef31a8f0eafe5a896427dca10e80f7569341bcec2c4b8179e3","sello":"853105423859f1900194f0b827287f4b4ec2c4a958050e8203f7ae5b12a3ca55","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6587632,"aleatorio":"e5f4501cec646e43fc02e0fe1fe4a007971ca7f76b2ee59bcfa3c5f64bf15567","tiempo":"2026-10-27T00:13:00.000Z"},"nist":{"cadena":2,"pulso":2001009,"salida":"D40E14007D6713315067C4542F3D7D0FF922C8FB815DB05FEACE37847166032AAD7591924E5D2623E17D17CD6D56FA07A2A5696B5751C1B97915B1C932BE8E75","tiempo":"2026-10-27T00:12:00.000Z"},"noAntes":"2026-10-27T00:13:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 27 00:13:42 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Cornealia: automated collective order analysis reveals density-dependent reorganization of donor corneal endothelium","descripcion":"The corneal endothelium is a non-regenerative monolayer whose health determines transplant success, yet donor tissue is assessed only by single-cell metrics that ignore how the monolayer is organized collectively. A physics-based spring constant K, derived from the radial distribution function of cell positions, captures this collective order but has remained limited to semi-manual studies without physical interpretation. Here we present Cornealia, an automated pipeline for collective-order and intercellular-force analysis. In cultured endothelial cells, collective order declines with passaging and is higher under growth-factor conditions that preserve N-cadherin junctions, differences invis","pubDate":"2026-10-26","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760745v1?rss=1"},"indexado":"2026-10-27T00:12:40.142Z"}}