{"ok":true,"nota":{"id":"3bf622100ce6808f","slug":"crearon-un-mapa-de-datos-geneticos-para-estudiar-la-enfermedad-de-croh-3bf622","titulo":"Crearon un mapa de datos genéticos para estudiar la enfermedad de Crohn y la colitis ulcerosa","resumen":"Un equipo armó IBDex, una herramienta basada en 3.168 biopsias de intestino de 1.680 pacientes con enfermedad inflamatoria intestinal o sin ella. El objetivo es que nuevos estudios puedan usar ese mapa sin tener que entrenar sus propios modelos desde cero.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Madeswaran, A. K., Acharjee, A.","url":"https://www.medrxiv.org/content/10.64898/2026.10.20.26365993v1?rss=1","imagen":"/hoy/portada/3bf622100ce6808f","tema":"salud","subtemas":["enfermedad de crohn","colitis ulcerosa","biopsias intestinales","inteligencia artificial medica","transcriptomica"],"entidades":["IBDex","medRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T22:02:10.728Z","hash":"e3d96b77f11af9196d4dfa04a97743fea65897966925d8fa244b8c13b2427e03","tsa":{"time":"Oct 22 22:02:56 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Para quienes conviven con Crohn o colitis ulcerosa, el diagnóstico y el seguimiento dependen de entender qué pasa en el intestino a nivel molecular. Un mapa común que se pueda reutilizar acelera la búsqueda de tratamientos y ahorra tiempo y plata a los centros de investigación. Si la herramienta funciona en pacientes de otros países, también podría servir en hospitales argentinos. Aun así, todavía está en fase de preprint y falta comprobar cómo se comporta con pacientes reales de acá.","quienFirma":"Equipo de investigación internacional (preprint en medRxiv)","confianza":"preprint","consulta":null},"sello":{"hash":"e3d96b77f11af9196d4dfa04a97743fea65897966925d8fa244b8c13b2427e03","sello":"3aa4914f7ec24a1a93f6db70fcd32d54ef306701b58bb2ade0eff1e308db8a7b","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575851,"aleatorio":"29e6764b49393fcb685b41ab04eb6667b179de6b518c8212d4aa11d1de9d1b19","tiempo":"2026-10-22T22:02:30.000Z"},"nist":{"cadena":2,"pulso":1995125,"salida":"70391569C3CDB488E71ABC660C5481B4A24B300E2E08E833696854B6488DAB0370809D6AA479035A0F6218DCEDD92C536F46C33AF62EF2BFF2B7635A2FD7E526","tiempo":"2026-10-22T22:02:00.000Z"},"noAntes":"2026-10-22T22:02:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 22:02:56 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"IBDex: A Frozen Patient-Scale Atlas for Bulk Transcriptomics in Inflammatory Bowel Disease","descripcion":"Background and Aims: Bulk mucosal RNA sequencing in inflammatory bowel disease (IBD) is analyzed one cohort at a time, so each study rebuilds its own molecular scale. We aimed to build a frozen atlas that new cohorts could use without retraining. Methods: We built IBDex from 3,168 intestinal biopsies from 1,680 patients with Crohn's disease, ulcerative colitis or no IBD, drawn from four cohorts. Patients were kept within a single training, validation or test partition. A tissue-aware conditional variational autoencoder with adversarial suppression of cohort identity was trained on a 3,000-gene interface. The scaling, encoder, decoder, pathway basis and phenotype directions were then frozen. ","pubDate":"2026-10-22","url":"https://www.medrxiv.org/content/10.64898/2026.10.20.26365993v1?rss=1"},"indexado":"2026-10-22T22:02:10.728Z"}}