{"ok":true,"nota":{"id":"3b012dd6a7f4b82f","slug":"mutaciones-en-la-sangre-aparecen-tambien-en-adultos-jovenes-y-mas-de-l-3b012d","titulo":"Mutaciones en la sangre aparecen también en adultos jóvenes, y más de lo que se pensaba","resumen":"Analizaron el ADN de casi 60 mil adultos de Nueva York para detectar clones de células sanguíneas con mutaciones, un cambio que se asocia con la edad, y cómo varía según origen genético y edad.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Esai Selvan, M., Ashraf, N., Pradeep, R., Giordano, L., Dougherty, M., Chevelev, P., Neuse, C. J., Nathan, D. I., Marcel","url":"https://www.medrxiv.org/content/10.64898/2026.10.22.26366221v1?rss=1","imagen":"/hoy/portada/3b012dd6a7f4b82f","tema":"salud","subtemas":["genética","células sanguíneas","envejecimiento","mutaciones","medicina de precisión"],"entidades":["Mount Sinai","Nueva York"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T16:44:38.283Z","hash":"b0cbb994542eaca4b14c94b9d777fef09c898985b5c0cde4623e2614b9a40f65","tsa":{"time":"Oct 26 16:45:05 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Como la muestra es muy diversa en orígenes genéticos, sirve para entender que el riesgo no se reparte igual en todos los grupos. Para alguien de acá, la lectura es que la salud de la sangre se empieza a deteriorar antes de lo que uno cree, y que los controles no deberían esperar a la vejez.","quienFirma":"Icahn School of Medicine at Mount Sinai","confianza":"preprint","consulta":null},"sello":{"hash":"b0cbb994542eaca4b14c94b9d777fef09c898985b5c0cde4623e2614b9a40f65","sello":"9b95fa39d766bb466c6651dab8963cd64da5251a383ab5688c2000600a0d75d7","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6586735,"aleatorio":"d652840fb123328052c3030159166310d2cc2c3a7fbda704f6b84204deba9384","tiempo":"2026-10-26T16:44:30.000Z"},"nist":{"cadena":2,"pulso":2000561,"salida":"92BFEF28BAC2624F31453300FB5A36A052C23007805C3D408BFF1C806F7A59ED220625D284E153B6009649B8250F544E883A7C10F29CB2756BB3E5CCE4B3B698","tiempo":"2026-10-26T16:44:00.000Z"},"noAntes":"2026-10-26T16:44:30.000Z"},"verificacion":{"drand":true,"nist":"inaccesible"},"tsa":{"time":"Oct 26 16:45:05 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"The genetic, clinical and immune landscape of clonal hematopoiesis across adulthood in the multi-ancestry Mount Sinai Million cohort","descripcion":"Clonal hematopoiesis of indeterminate potential (CHIP), the age-associated expansion of blood cell clones carrying acquired driver mutations, remains less well characterized in young adults, across genetic ancestries, and in clinical populations. We analyzed whole-exome sequencing and longitudinal electronic health record (EHR) data from 59,598 adults in the Mount Sinai Million Health Discoveries Program, an urban, multi-ancestry hospital-based cohort that includes substantial representation of African ([~]35%) and Admixed American genetic ancestry ([~]15%) and young adults aged 18-39 years ([~]30%). After sample QC, separate analyses were performed in discovery (n = 28,051) and validation (","pubDate":"2026-10-26","url":"https://www.medrxiv.org/content/10.64898/2026.10.22.26366221v1?rss=1"},"indexado":"2026-10-26T16:44:38.283Z"}}