{"ok":true,"nota":{"id":"3a832ac3cdbe3969","slug":"un-estimulo-cerebral-para-la-epilepsia-deja-una-huella-reconocible-en--3a832a","titulo":"Un estímulo cerebral para la epilepsia deja una huella reconocible en el EEG","resumen":"Investigadores estudiaron a cinco pacientes con epilepsia resistente a medicamentos, a quienes se les estimula una zona profunda del tálamo con electrodos. Registraron la actividad eléctrica del cuero cabelludo en diez sesiones, un año después de la primera. Encontraron un patrón de actividad que se repitió en ambas mediciones.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Sabbaghi, E., Mattila, H., Siitama, E., Hyttinen, J., Peltola, J., Puthanmadam Subramaniyam, N.","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759433v1?rss=1","imagen":"/hoy/portada/3a832ac3cdbe3969","tema":"salud","subtemas":["epilepsia","estimulación cerebral profunda","electroencefalograma","neurología"],"entidades":["bioRxiv","núcleo anterior del tálamo"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T21:54:18.823Z","hash":"384bd8c5e8f3d2d2750b7cf44d1ba1eefb5a3f642eb84d9c82fbb586c67d2098","tsa":{"time":"Oct 22 21:55:20 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Para una persona con epilepsia que no responde a los medicamentos, el tratamiento con estimulación profunda ya existe, pero medir si funciona es complicado. Un patrón que se repite entre sesiones y entre años podría servir para ajustar el tratamiento sin depender solo de lo que el paciente describe. El estudio es chico, con solo cinco personas, y todavía es un trabajo preliminar que no ha sido revisado por pares.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"384bd8c5e8f3d2d2750b7cf44d1ba1eefb5a3f642eb84d9c82fbb586c67d2098","sello":"0fca46dfc1257ad5d08182461a1d9c8dfce51f9bab4fc50f83d21a3db756c536","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575836,"aleatorio":"a8739c6f28d7e03ed191a881119536d56c373334288c8dc3d26ef33eb54db44f","tiempo":"2026-10-22T21:55:00.000Z"},"nist":{"cadena":2,"pulso":1995117,"salida":"932C769A8B73E2CC53835512DA1C7CF78DC4B06757B136D8DCC28C89B61C25ED52E0DD74B99E06F83F83805D89C905466FC5BF54DA4D037DEA5F5312DBA4C659","tiempo":"2026-10-22T21:54:00.000Z"},"noAntes":"2026-10-22T21:55:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 21:55:20 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Acute scalp EEG signatures of anterior thalamic DBS in epilepsy:reproducible gamma power enhancement within an aperiodic spectral-state shift","descripcion":"Background: Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is an established treatment for drug-resistant epilepsy, but acute scalp-EEG signatures of stimulation remain incompletely characterized. Objective: To identify acute scalp-EEG signatures of ANT-DBS and assess their cross-year reproducibility in a proof-of-concept repeated-session cohort. Methods: Scalp EEG from five patients recorded one year apart (10 sessions) was analyzed during nominal cyclic DBS (1 s ON, ~5 s OFF). DBS ON was compared with the within-cycle OFFmean and consecutive post-offset OFF windows using power spectral density (PSD), spatiotemporal-frequency (STF) analysis, and spectral paramete","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759433v1?rss=1"},"indexado":"2026-10-22T21:54:18.823Z"}}