{"ok":true,"nota":{"id":"36fbbc4b95395737","slug":"encontraron-variantes-de-una-proteina-ligadas-a-la-infertilidad-mascul-36fbbc","titulo":"Encontraron variantes de una proteína ligadas a la infertilidad masculina, probadas en embriones de pez cebra","resumen":"Investigadores analizaron variantes genéticas de la proteína NANOS en hombres con infertilidad y desarrollaron un ensayo rápido en embriones de pez cebra para medir su actividad biológica. Con esa combinación identificaron variantes que podrían contribuir a la infertilidad masculina.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Madiwale, S., Gupta, A., Schmidthuis, L., Krausz, C. G., Bonini, V., Kliesch, S., Friedrich, C., Tuettelmann, F., Raz, E","url":"https://www.medrxiv.org/content/10.64898/2026.10.20.26366003v1?rss=1","imagen":"/hoy/portada/36fbbc4b95395737","tema":"ciencia","subtemas":["infertilidad masculina","genética","pez cebra","fertilidad","investigación biomédica"],"entidades":["NANOS","pez cebra"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-24T00:00:00.000Z","indexTs":"2026-10-24T16:15:25.143Z","hash":"7a058ca5e5c0640e840f1cbd690d3255a4a6c45a99bc02d85519bcb6cd1b9c0e","tsa":{"time":"Oct 24 16:15:47 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Cerca del 17% de la población masculina tiene algún problema de fertilidad, pero asociar un gen concreto a ese problema es muy difícil. Este trabajo ofrece una herramienta barata y rápida para testear si una variante genética realmente altera la función de la proteína, algo que hasta ahora llevaba años. Para una pareja que busca hijos sin resultados, eso puede acercar un diagnóstico con nombre y apellido. Lo que todavía falta es saber si estas variantes explican casos en la población general.","quienFirma":"Institución no identificada en el extracto","confianza":"preprint","consulta":null},"sello":{"hash":"7a058ca5e5c0640e840f1cbd690d3255a4a6c45a99bc02d85519bcb6cd1b9c0e","sello":"16a3ef0966749e134808c5dea9102d6481ae3167f40b93920c173ec9a3486514","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6580917,"aleatorio":"a7ae54c0fcfc9c8a83fe34d0f9320d7528705afd5812276babb4293af5018488","tiempo":"2026-10-24T16:15:30.000Z"},"nist":{"cadena":2,"pulso":1997652,"salida":"9FC650564FC506D017D213281A32AA6072901F0F4F8883A3D1F9DA96496268E453F30EEB00C0821C4D971088ECA97156340102106DF3CD979C769CA0CDF67C37","tiempo":"2026-10-24T16:15:00.000Z"},"noAntes":"2026-10-24T16:15:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 24 16:15:47 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Functional analysis of NANOS protein variants identified in men with infertility employing zebrafish embryos","descripcion":"Study question: Are vertebrate NANOS proteins associated with human fertility, and can a rapid in vivo assay in zebrafish be established to evaluate the biological activity of human NANOS variants? Summary answer: Combining a rapid in vivo assay we developed for Nanos protein activity and patient-derived genetic data, we identified NANOS variants that could contribute to male infertility. What is known already: Male infertility affects approximately 17% of the population, but linking specific gene variants to this condition remains challenging. NANOS proteins are essential regulators of germ cell development in different model organisms; however, a rapid and robust in vivo assay for evaluati","pubDate":"2026-10-24","url":"https://www.medrxiv.org/content/10.64898/2026.10.20.26366003v1?rss=1"},"indexado":"2026-10-24T16:15:25.143Z"}}