{"ok":true,"nota":{"id":"362e8fa0a84825d0","slug":"un-nuevo-metodo-permite-medir-la-herencia-genetica-en-poblaciones-muy--362e8f","titulo":"Un nuevo método permite medir la herencia genética en poblaciones muy mezcladas, no solo en europeos","resumen":"Un equipo desarrolló SUMMIT, un método estadístico que usa datos de estudios de asociación genética para estimar cuánto influye la genética en rasgos humanos. Lo probaron con simulaciones en poblaciones europeas y de otras ascendencias, incluyendo grupos mezclados.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Jeong, M., Liu, Z., Ni, J., An, U., Han, S., Anand, A., Anand, P., Boffelli, M., Sankararaman, S.","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760508v1?rss=1","imagen":"/hoy/portada/362e8fa0a84825d0","tema":"ciencia","subtemas":["genetica poblacional","estudios de asociacion genomica","herencia genetica","diversidad genetica","metodos estadisticos"],"entidades":["SUMMIT","bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T10:38:41.125Z","hash":"cc81319fb0df30563093a264b99a76f9f3f11dce4499e21e6553616d198dad6a","tsa":{"time":"Oct 22 10:39:09 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hasta ahora buena parte de la investigación genética se hizo con poblaciones europeas, lo que deja afuera a gran parte de la humanidad. Un método que funcione en grupos mezclados permite estudiar enfermedades que afectan a personas de acá con mayor precisión. El trabajo sigue siendo una simulación y no está revisado por pares, así que falta probarlo con datos reales.","quienFirma":"Preprint en bioRxiv (institución principal no identificada en la descripción)","confianza":"preprint","consulta":null},"sello":{"hash":"cc81319fb0df30563093a264b99a76f9f3f11dce4499e21e6553616d198dad6a","sello":"560c03c586e30e74b32275ec4afed1697cfd6498c60be0f536867d17e328c2f3","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6574483,"aleatorio":"9801d1332798cbede2bf7a79e77928f4f345c08d34dd79d1c4c9c9c73783e9de","tiempo":"2026-10-22T10:38:30.000Z"},"nist":{"cadena":2,"pulso":1994441,"salida":"917B00588BBAF41DD8C461E7D93EA47DC73C00983776285722380061C2505D68D1C49D178A1E9E1A422EEA35DB6367141AB79828DD0F9592CE1805F752B02469","tiempo":"2026-10-22T10:32:00.000Z"},"noAntes":"2026-10-22T10:38:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 10:39:09 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Genome-wide LD scores enable robust heritability and genetic correlation estimation from summary statistics across genetic ancestries","descripcion":"Our knowledge of human complex trait architecture across diverse populations remains limited. Estimating SNP heritability and genetic correlation from GWAS summary statistics - successful in revealing genetic architecture in homogeneous cohorts - is challenging in structured and admixed populations due, in part, to the difficulty of representing long-range LD. We present SUMMIT, a statistical framework that combines genome-wide LD scores, efficiently estimated using random projections, with GWAS summary statistics to estimate genome-wide and annotation-specific heritability and genetic correlation. In simulations that explore diverse aspects of genetic architecture across European (EUR), Sou","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760508v1?rss=1"},"indexado":"2026-10-22T10:38:41.125Z"}}