{"ok":true,"nota":{"id":"345cb4cb233b6246","slug":"un-mismo-patron-de-envejecimiento-del-musculo-aparece-en-especies-muy--345cb4","titulo":"Un mismo patrón de envejecimiento del músculo aparece en especies muy distintas","resumen":"Compararon el ARN de músculos de seis especies de distintas ramas evolutivas, de jóvenes y viejos, separados por sexo. Buscaron marcadores moleculares de envejecimiento que se repitan entre especies y que dependan del sexo.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Randolph, E. C., Fang, Y., Meisel, R., Walters, J., Gamble, T., Wilkinson, G., Larschan, E., Webb, A., IISAGE Consortium","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759636v1?rss=1","imagen":"/hoy/portada/345cb4cb233b6246","tema":"ciencia","subtemas":["envejecimiento","musculo","diferencias entre sexos","biomarcadores","longevidad"],"entidades":["mamiferos","aves"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T21:54:18.823Z","hash":"5ab0005336e50a80fd5e5f8092bdc748d8295d8e7b602ce387c9cff42992ebbb","tsa":{"time":"Oct 22 21:55:19 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Saber qué cambios moleculares acompañan al envejecimiento del músculo permite medir cuán viejo está un tejido, no solo cuántos años tiene una persona. Que algunos marcadores se repitan entre especies sugiere mecanismos antiguos y compartidos, lo que da pistas para entender la pérdida de masa muscular en la vejez. Es un estudio de comparación entre especies, así que traducirlo a un análisis de sangre o de biopsia para una persona todavía es un paso lejano.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"5ab0005336e50a80fd5e5f8092bdc748d8295d8e7b602ce387c9cff42992ebbb","sello":"a334d8c139dbecb98df993cb80e193fef584413eca231b50adfd1f0911263cc6","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575836,"aleatorio":"a8739c6f28d7e03ed191a881119536d56c373334288c8dc3d26ef33eb54db44f","tiempo":"2026-10-22T21:55:00.000Z"},"nist":{"cadena":2,"pulso":1995117,"salida":"932C769A8B73E2CC53835512DA1C7CF78DC4B06757B136D8DCC28C89B61C25ED52E0DD74B99E06F83F83805D89C905466FC5BF54DA4D037DEA5F5312DBA4C659","tiempo":"2026-10-22T21:54:00.000Z"},"noAntes":"2026-10-22T21:55:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 21:55:19 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Common and Sex-Biased Muscle Transcriptomic Aging Signatures Across Diverse Species","descripcion":"Sex differences in lifespan are widespread yet inconsistent across the animal kingdom. In mammals, XX females outlive XY males in over 60% of species, while this pattern reverses in birds, where ZZ males have a higher life expectancy. These sex differences raise the question of whether sex-biased aging biomarkers (age-associated molecular signatures that reflect biological aging processes) can be identified based on transcriptomic data and whether such markers are shared across taxa. To identify sex-biased aging biomarkers, we analyzed sex-specific skeletal muscle transcriptomes (RNA-seq) from young and old individuals of six species spanning major evolutionary lineages. Four female-biased a","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759636v1?rss=1"},"indexado":"2026-10-22T21:54:18.823Z"}}