{"ok":true,"nota":{"id":"333385c84649a876","slug":"una-proteina-de-la-mosca-de-la-fruta-resulta-ser-un-nuevo-regulador-de-333385","titulo":"Una proteína de la mosca de la fruta resulta ser un nuevo regulador del gen Myc, vinculado al crecimiento celu","resumen":"Investigadores identificaron en la mosca Drosophila una proteína llamada POSH que interactúa con Myc, un gen que regula el crecimiento. Lo detectaron en un tamizaje genético y lo confirmaron con un transgén.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Kuo, V., Daniel, M., Zola, S., Bellosta, P.","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760028v1?rss=1","imagen":"/hoy/portada/333385c84649a876","tema":"ciencia","subtemas":["gen myc","drosophila","crecimiento celular","investigación oncológica","señalización celular"],"entidades":["bioRxiv","Drosophila melanogaster"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-20T12:15:39.527Z","hash":"56e88d5b40106a710742e82c1ba57ae6bb57ac68317c9f3dbafe86cd5ebaccc1","tsa":{"time":"Oct 20 12:17:24 2026 GMT","provider":"freetsa.org"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Myc es un gen que aparece alterado en muchos cánceres, así que entender qué señales traducen su actividad en respuestas concretas de la célula importa para la investigación oncológica. Este hallazgo agrega un actor nuevo a esa cadena, aunque se hizo en moscas y todavía falta mucho para cualquier aplicación en personas. Para el lector común, es una pieza más en el rompecabezas de cómo se regula el crecimiento de nuestras células.","quienFirma":"bioRxiv (preprint; laboratorio de biología del desarrollo en Drosophila)","confianza":"preprint","consulta":null},"sello":{"hash":"56e88d5b40106a710742e82c1ba57ae6bb57ac68317c9f3dbafe86cd5ebaccc1","sello":null,"beacon":null,"verificacion":null,"tsa":{"time":"Oct 20 12:17:24 2026 GMT","provider":"freetsa.org"},"original":{"titulo":"POSH (Plenty of SH3): a novel genetic modifier of Myc function in Drosophila","descripcion":"Abstract: MYC is a conserved transcriptional regulator that coordinates cellular growth, metabolism, and tissue homeostasis through a broad network of downstream effectors. However, the signaling components that translate MYC activity into specific cellular responses remain incompletely defined. Here, using Drosophila melanogaster, we identify Plenty of SH3s (POSH), a conserved RING-domain scaffold protein and regulator of JNK signaling, as a novel genetic interactor of Myc. POSH was identified in a genetic screen for modifiers of a Myc-dependent phenotype in the developing eye. The interaction was independently confirmed using a UAS-Posh transgene. Quantitative analysis showed that reduced ","pubDate":"2026-10-20","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760028v1?rss=1"},"indexado":"2026-10-20T12:15:39.527Z"}}