{"ok":true,"nota":{"id":"3039e2f05a98eb03","slug":"ratones-con-una-mutacion-similar-al-enanismo-leve-envejecen-antes-sus--3039e2","titulo":"Ratones con una mutación similar al enanismo leve envejecen antes sus huesos y músculos","resumen":"En ratones con una variante del gen FGFR3, asociada a una forma leve de displasia ósea, los investigadores observaron huesos frágiles, cartílagos y músculos más débiles con la edad. Hallaron además alteraciones en las mitocondrias de la médula y el hueso.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Fayad, C., Gatto, G., Blouin, S., Tamas, M., Hartmann, M. A., Milunov, D., Guerrera, I. C., Saha, S., Figueroa, A., Bona","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759608v1?rss=1","imagen":"/hoy/portada/3039e2f05a98eb03","tema":"ciencia","subtemas":["envejecimiento","displasia ósea","mitocondrias","músculos","genética"],"entidades":[],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T16:38:44.280Z","hash":"d9913c96e67e7747d6fe6ee1b747dac8f48e0e7145e000e3125f76e4f53fefdf","tsa":{"time":"Oct 22 16:39:28 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Las personas con hipocondroplasia suelen tener una vida normal, pero este trabajo sugiere que sus huesos y músculos podrían desgastarse antes de lo esperado. Si el problema pasa por las mitocondrias, las células que producen energía, en el futuro podría haber formas de frenar ese deterioro. Hoy el seguimiento de estos pacientes no contempla ese riesgo.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"d9913c96e67e7747d6fe6ee1b747dac8f48e0e7145e000e3125f76e4f53fefdf","sello":"bced196c9a5095a3e93714fc020c797d09b2ef557cd11401c00260a7aff71439","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575204,"aleatorio":"ac0f4a6ce509202540c9641abb3a70f7f06eeb36f68a34e1bc3e430369a775da","tiempo":"2026-10-22T16:39:00.000Z"},"nist":{"cadena":2,"pulso":1994801,"salida":"123765DCC46130497358D1E6393BF76FC82D205E2F260DEF171C4887B733C1209F31A193DDD877AB50C2E9F79D0A125A26712AD900F817275AC0E40E5C1C39BC","tiempo":"2026-10-22T16:38:00.000Z"},"noAntes":"2026-10-22T16:39:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 16:39:28 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Mitochondrial dysfunction plays a key role in premature musculoskeletal aging in hypochondroplasia mouse model","descripcion":"Hypochondroplasia (HCH) is a mild form of chondrodysplasia, caused by variants in fibroblast growth factor receptor 3 (FGFR3). Today, the biological mechanism underlying musculoskeletal aging in HCH remains largely unknown. In this study, we show that Hch mice exhibit phenotypic traits of bone fragility and accelerated age-dependent articular cartilage and subchondral bone changes. Hch mice also presented decreased muscle strength and reduction in muscle fibers size. Furthermore, proteomics analyses of the cortical bone revealed that Hch mice follow a different aging trajectory than control. FGFR3 mutation leads to a premature boost of the mitochondrial processes forcing the mutant to reach ","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759608v1?rss=1"},"indexado":"2026-10-22T16:38:44.280Z"}}