{"ok":true,"nota":{"id":"2f05a79d5500df46","slug":"el-reloj-interno-de-las-moscas-no-alcanza-solo-la-cromatina-regula-cua-2f05a7","titulo":"El reloj interno de las moscas no alcanza solo: la cromatina regula cuándo se activan los genes","resumen":"Estudiaron las neuronas fotorreceptoras de la retina de la mosca Drosophila. Vieron que los factores de transcripción del reloj circadiano explican el momento de activación de solo una minoría de los genes rítmicos.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Meng, G., McGovern, S. E., Kramer, L. D., Martinez Zamudio, R. I., Weake, V. M.","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759625v1?rss=1","imagen":"/hoy/portada/2f05a79d5500df46","tema":"ciencia","subtemas":["ritmos circadianos","epigenetica","retina","genes","drosophila"],"entidades":["Drosophila"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T21:54:18.823Z","hash":"6c70513773cb6b6574200aa21ec9f7907ee9723873d823ed42ad0e31a8e0d78c","tsa":{"time":"Oct 22 21:55:20 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Los ritmos del día son los que mantienen sana la retina, y cuando se rompen la retina se degenera. Este trabajo muestra que el control del día pasa también por cómo está empaquetado el ADN, no solo por el reloj central. Como el estudio es en moscas, su aplicación a la retina humana es una hipótesis que deberá probarse en otros organismos.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"6c70513773cb6b6574200aa21ec9f7907ee9723873d823ed42ad0e31a8e0d78c","sello":"32fa4c06f0ac53d72fdaaab7cecff4fed964109c725b20644494c1d411a3fa04","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575836,"aleatorio":"a8739c6f28d7e03ed191a881119536d56c373334288c8dc3d26ef33eb54db44f","tiempo":"2026-10-22T21:55:00.000Z"},"nist":{"cadena":2,"pulso":1995117,"salida":"932C769A8B73E2CC53835512DA1C7CF78DC4B06757B136D8DCC28C89B61C25ED52E0DD74B99E06F83F83805D89C905466FC5BF54DA4D037DEA5F5312DBA4C659","tiempo":"2026-10-22T21:54:00.000Z"},"noAntes":"2026-10-22T21:55:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 21:55:20 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Chromatin states coordinate diurnal gene expression in the Drosophila retina","descripcion":"Daily biological rhythms enable organisms to anticipate and respond to predictable diurnal environmental changes. While the circadian clock maintains rhythms under constant conditions, it remains unclear what gates the time-of-day expression of genes that are rhythmic under light:dark cycles. In the retina, restricting biological processes to specific times of the day is crucial for homeostasis because disrupting these rhythms causes retinal degeneration. We show that in light-sensitive photoreceptor neurons of Drosophila, the circadian transcription factors only account for the timing of a minority of rhythmic genes. Instead, integrative analysis of the daily chromatin landscape and transcr","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759625v1?rss=1"},"indexado":"2026-10-22T21:54:18.823Z"}}