{"ok":true,"nota":{"id":"2d3454938fd7f826","slug":"descubren-como-una-proteina-repara-el-adn-clave-para-pensar-tratamient-2d3454","titulo":"Descubren cómo una proteína repara el ADN, clave para pensar tratamientos contra el cáncer","resumen":"Investigadores del St. Jude Children's Research Hospital describieron el mecanismo por el cual la proteína PARP1 participa en la reparación del ADN dañado. El trabajo se publicó en la revista Molecular Cell.","fuente":"phys","fuenteNombre":"Phys.org","color":"#2b5c8a","autor":"","url":"https://phys.org/news/2026-10-mechanism-parp1-dna-characterized-insight.html","imagen":"https://scx1.b-cdn.net/csz/news/tmb/2026/mechanism-behind-parp1.jpg","tema":"salud","subtemas":["cancer","reparacion-adn","parp1","terapias-dirigidas","oncologia"],"entidades":["St. Jude Children's Research Hospital","Molecular Cell","PARP1"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T18:40:01.000Z","indexTs":"2026-10-23T18:41:33.690Z","hash":"84514f19cb00787891b1e385dc0637f0448b3b425ad05351ea70179e20cb9c0b","tsa":{"time":"Oct 23 18:41:54 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Algunos tumores tienen fallas en su capacidad para reparar el ADN, y frenar esa reparación puede ser justamente lo que los vuelve vulnerables. Conocer cómo funciona PARP1 ayuda a diseñar medicamentos más precisos para ciertos cánceres. Para un paciente o una familia, esto significa que la investigación básica empieza a apuntar a tratamientos más dirigidos, aunque todavía falta mucho camino hasta llegar a la clínica.","quienFirma":"St. Jude Children's Research Hospital","confianza":"divulgacion","consulta":null},"sello":{"hash":"84514f19cb00787891b1e385dc0637f0448b3b425ad05351ea70179e20cb9c0b","sello":"31641595cc32f7c87c7696a6f2b8bd013b2333bc28824fe00886d20f4c802a71","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6578329,"aleatorio":"e6081be7b8d77d4ec89120b07280d26952ddc20c8194113a5cae9c5a5c71734b","tiempo":"2026-10-23T18:41:30.000Z"},"nist":{"cadena":2,"pulso":1996358,"salida":"436DDDF1C3A843C910F98D9F276A99E6E949F93BEA03E29F32A07D9FEBDC0D2C3EF4BCBE198BB3F2E55DFD72B93D643B01043F79672BEFFFFB435C4CE82D7624","tiempo":"2026-10-23T18:41:00.000Z"},"noAntes":"2026-10-23T18:41:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 18:41:54 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Mechanism behind PARP1-mediated DNA repair characterized, offering insight into targeted cancer therapy","descripcion":"When DNA is damaged, cellular processes respond and repair the DNA. Inhibiting DNA damage repair can be therapeutically beneficial in cancers with genetic vulnerabilities related to DNA damage response. Scientists at St. Jude Children's Research Hospital have uncovered a mechanism behind how this process works, which may have implications for cancer treatment. The results were published today in Molecular Cell.","pubDate":"Fri, 23 Oct 2026 14:40:01 EDT","url":"https://phys.org/news/2026-10-mechanism-parp1-dna-characterized-insight.html"},"indexado":"2026-10-23T18:41:33.690Z"}}