{"ok":true,"nota":{"id":"2a27da01ebfc2b58","slug":"un-sensor-cuantico-genetico-mide-el-ph-dentro-de-organelos-de-la-celul-2a27da","titulo":"Un sensor cuántico genético mide el pH dentro de organelos de la célula viva","resumen":"Investigadores probaron MagLOV2, un sensor codificado genéticamente que responde a campos magnéticos y mide el pH en citoplasma, núcleo y mitocondrias. Lo optimizaron para seguir cambios dinámicos dentro de células vivas.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Seki, M., Aizawa, S., Shigeno, Y., Maita, N., Chen, S., Kato, M., Ogasawara, S., Murata, T., Antill, L. M., Ishiwata, H.","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760020v1?rss=1","imagen":"/hoy/portada/2a27da01ebfc2b58","tema":"ciencia","subtemas":["biologia celular","sensores cuanticos","mitocondrias","ph celular","imagenes biologicas"],"entidades":["MagLOV2","bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-20T12:15:39.527Z","hash":"a134964a5c34f54212975023ba168203790bc3054df68c5bdb4c6f6c787f7f5e","tsa":{"time":"Oct 20 12:17:09 2026 GMT","provider":"freetsa.org"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hasta ahora medir el pH dentro de cada compartimento de una célula era casi imposible sin dañarla, y esto da una herramienta que se puede dejar dentro del tejido vivo. Eso sirve para entender enfermedades donde las mitocondrias fallan, que afectan a muchas personas en el país sin que se sepa bien por qué. Es un paso de laboratorio, pero señala una forma nueva de mirar lo que pasa adentro de nosotros.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"a134964a5c34f54212975023ba168203790bc3054df68c5bdb4c6f6c787f7f5e","sello":null,"beacon":null,"verificacion":null,"tsa":{"time":"Oct 20 12:17:09 2026 GMT","provider":"freetsa.org"},"original":{"titulo":"Organelle-Specific pH Quantification Using a Protein-Based Quantum Sensor","descripcion":"Quantum sensing enables measurements of physicochemical changes within living cells at the organelle level. Conventional nanoparticle-based sensors, however, face limitations in subcellular targeting, intracellular tracking, and following dynamic biological processes across distinct intracellular environments. Here, we investigate MagLOV2, a genetically encoded quantum sensor, by examining its organelle-specific localization, magnetic field effects (MFEs) during mitophagy, and pH dependent response kinetics. MagLOV2 retained magnetic responsiveness in the cytoplasm, nucleus, and mitochondria, with fluorescence contrasts of 17.1%, 12.3%, and 28.0%, respectively. Optimization of mitochondrial ","pubDate":"2026-10-20","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760020v1?rss=1"},"indexado":"2026-10-20T12:15:39.527Z"}}