{"ok":true,"nota":{"id":"257e66eb242a849e","slug":"en-gusanos-sin-celulas-germinales-una-proteina-del-reciclaje-celular-a-257e66","titulo":"En gusanos sin células germinales, una proteína del reciclaje celular alarga la vida","resumen":"Investigadores eliminaron una parte específica de una proteína de reciclaje celular en el gusano C. elegans, un organismo modelo muy usado en biología. Observaron efectos sobre el funcionamiento de los lisosomas y sobre la longevidad de los animales.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Ebata, H., Dogra, S. K., Sun, L.-H., Buggs, D., Doroodian, S., Linkous, A., Hodul, M., Kao, A. W., Hansen, M.","url":"https://www.biorxiv.org/content/10.64898/2026.10.14.758959v1?rss=1","imagen":"/hoy/portada/257e66eb242a849e","tema":"ciencia","subtemas":["envejecimiento","autofagia","c-elegans","lisosomas","biologia-celular"],"entidades":["C. elegans","ATG16L1"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-21T05:32:19.019Z","hash":"81f4b40c9253f2f0b884d2fbae7f06570fd401e4bea810bec81632b18600c93c","tsa":{"time":"Oct 21 05:32:48 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Esto sugiere que el reciclaje celular tiene un papel propio en la duración de la vida, separado de la reproducción. Para alguien de acá, es una pista de cómo funcionan los mecanismos básicos del envejecimiento, aunque todavía falta mucho para saber si aplica a personas. Un gusano no es un humano, y pasar de este hallazgo a una promesa de vida más larga sería un salto injustificado.","quienFirma":"bioRxiv (preprint; institución principal no identificada en el extracto)","confianza":"preprint","consulta":null},"sello":{"hash":"81f4b40c9253f2f0b884d2fbae7f06570fd401e4bea810bec81632b18600c93c","sello":"02ab54b0cf067100d55ceb6179f8985b7b51d4af0371d5dfb4c4f388b075b1ca","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6570990,"aleatorio":"197cfefbaae84a11019800f736fb3d999fc9deaffc98cec0c35453a67bb3b551","tiempo":"2026-10-21T05:32:00.000Z"},"nist":{"cadena":2,"pulso":1992700,"salida":"779B9C05152B4CBD1C0DC8A789A98414BB1FB7FC9BCD4C986DB35B0B6DFFACF69BCA3C8A248326F1AFCD58751A3730795B71A1BBC058A265C3BB6F3B3B74127C","tiempo":"2026-10-21T05:31:00.000Z"},"noAntes":"2026-10-21T05:32:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 05:32:48 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"The WD40 domain of autophagy protein ATG-16.2 is required for lysosomal regulation and longevity in germline-less C. elegans","descripcion":"Autophagy is a conserved cellular recycling pathway linked to longevity and regulated by autophagy-related (ATG) protein. Many of these proteins serve a key function in ATG8 lipidation onto autophagosomal membranes, a step that precedes subsequent lysosomal degradation. Recently, mammalian ATG16L1, a member of ATG8 lipidation machinery, have been shown to also direct ATG8 lipidation onto other membranes via its C-terminal WD40 domain in acutely stressed cells. However, whether such non-canonical functions of the ATG16L1 WD40 domain influence longevity remain largely unknown. Here, we endogenously deleted the WD40 domain of atg-16.2, the C. elegans ortholog of ATG16L1, and examined autophagy,","pubDate":"2026-10-20","url":"https://www.biorxiv.org/content/10.64898/2026.10.14.758959v1?rss=1"},"indexado":"2026-10-21T05:32:19.019Z"}}