{"ok":true,"nota":{"id":"250bdc265dd1171c","slug":"personas-con-adrenoleucodistrofia-ligada-al-x-tienen-bacterias-intesti-250bdc","titulo":"Personas con adrenoleucodistrofia ligada al X tienen bacterias intestinales distintas según su forma de la enf","resumen":"Analizaron muestras de heces y sangre de pacientes con adrenoleucodistrofia ligada al X. Encontraron combinaciones de bacterias y metabolitos que cambian según el tipo de síntomas.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Torreni, L., Schluter, A., Marti, S., Ruiz, M., Velez Santamaria, V., Rodriguez-Palmero, A., Artuch, A., Guilera, C., Ar","url":"https://www.medrxiv.org/content/10.64898/2026.10.19.26365873v1?rss=1","imagen":"/hoy/portada/250bdc265dd1171c","tema":"salud","subtemas":["enfermedades raras","microbiota intestinal","adrenoleucodistrofia","metabolismo"],"entidades":["adrenoleucodistrofia ligada al X"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-20T23:32:18.927Z","hash":"3051ef5ca3f36ef068b9e8f574f960990497adfaa7dbbe26a5dfdc42a31a670f","tsa":{"time":"Oct 20 23:33:04 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La enfermedad varía mucho de una persona a otra, y no se sabe bien por qué. Este trabajo sugiere que lo que vive en el intestino podría ser parte de la explicación. Para las familias afectadas, abre una pista nueva aunque todavía lejos de cualquier tratamiento. Hay que tomarlo como una hipótesis: son pocos pacientes y no prueba que las bacterias causen la enfermedad.","quienFirma":"medRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"3051ef5ca3f36ef068b9e8f574f960990497adfaa7dbbe26a5dfdc42a31a670f","sello":"089cb79d42b1d230435277af7abbddd54eab546be5e63b031c317a8180f47d81","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6570272,"aleatorio":"bda24f270320f1e2527293c15ec727a66bdf246506dc957c7c9b6bd88c84b428","tiempo":"2026-10-20T23:33:00.000Z"},"nist":{"cadena":2,"pulso":1992341,"salida":"FA817D353D94A91CF41B4C174AAAB25209FED37DED6709559D325A28B103253A89D243C5C71B384CB4111753AA993F97FAC5CFB1C3257FDFA18ADA31FEE94D9A","tiempo":"2026-10-20T23:32:00.000Z"},"noAntes":"2026-10-20T23:33:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 20 23:33:04 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Gut microbiota dysbiosis in adrenoleukodystrophy: a new piece in the puzzle?","descripcion":"X-linked adrenoleukodystrophy (X-ALD) is the most common monogenic disorder affecting brain white matter, presenting a broad clinical spectrum from slowly progressive adrenomyeloneuropathy (AMN) to rapidly advancing cerebral demyelination. Factors influencing the variable disease expressivity remain poorly understood. We conducted shotgun metagenomic profiling of fecal samples from X-ALD patients and integrated these data with targeted plasma metabolomic analyses of amino acids and key metabolic intermediates. We identified distinct microbiome-associated metabolic signatures across X-ALD phenotypes. Notably, Bacteroides cellulosilyticus and Helicobacter apodemus abundance were significantly ","pubDate":"2026-10-20","url":"https://www.medrxiv.org/content/10.64898/2026.10.19.26365873v1?rss=1"},"indexado":"2026-10-20T23:32:18.927Z"}}