{"ok":true,"nota":{"id":"24a1414eebf0207d","slug":"una-proteina-clave-ayuda-a-las-celulas-de-defensa-a-moverse-por-el-cue-24a141","titulo":"Una proteína clave ayuda a las células de defensa a moverse por el cuerpo","resumen":"Investigadores identificaron la proteína Myo10 como regulador de la migración de células dendríticas, que activan la respuesta inmune. Al bloquearla en ratones, la respuesta de inflamación cutánea disminuyó y las células se movieron menos.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Gasilina, A., Sangsari, P. R., Badillo, N. M., Yim, Y.-I., Schrock, D., Morgan, N., Hammer, J.","url":"https://www.biorxiv.org/content/10.64898/2026.10.17.755813v1?rss=1","imagen":"/hoy/portada/24a1414eebf0207d","tema":"salud","subtemas":["sistema inmune","células dendríticas","migración celular","inflamación","investigación básica"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-20T14:45:48.401Z","hash":"5d7eac698227e66109236e9d25ffb5e9de052d43a930a98fe75b11949686ebb8","tsa":{"time":"Oct 20 14:47:48 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Las células dendríticas son como mensajeras que llevan la alerta del cuerpo hasta los linfocitos, y que puedan llegar a tiempo define cuán fuerte responde el sistema inmune. En el experimento, quitar la proteína Myo10 redujo la migración y la reacción cutánea, aunque no afectó la captura del antígeno. Es un hallazgo de biología básica en animales, todavía lejos de cualquier tratamiento para personas. Conviene desconfiar de quien lo presente como una cura próxima.","quienFirma":"Universidad no especificada en la fuente","confianza":"preprint","consulta":null},"sello":{"hash":"5d7eac698227e66109236e9d25ffb5e9de052d43a930a98fe75b11949686ebb8","sello":"c35c657bcb390cf5aef28ac358364cf0d5e45e950f596ce63d61aa1260a451d2","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6569221,"aleatorio":"78a7f8934232c63ef3863af8316612cf8aed7006c5554ae65e254f13cb50e27f","tiempo":"2026-10-20T14:47:30.000Z"},"nist":{"cadena":2,"pulso":1991816,"salida":"4BB483DC5B0F13488E37EC048E10F04D805F470BA4FF55509091158C428BE8E19FEEF29F893B00E5386D23DD98B5761B39AD81D267D35EBA482A5BDB4FBC6D51","tiempo":"2026-10-20T14:47:00.000Z"},"noAntes":"2026-10-20T14:47:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 20 14:47:48 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Myo10-dependent leading-edge coordination maintains physical coherence of migrating dendritic cells","descripcion":"Dendritic cells (DCs) are the principal leukocytes responsible for priming T cells. DC migration though geometrically complex tissue environments is crucial for initiating robust and spatiotemporally coordinated activation of adaptive immune responses. However, our understanding of the molecular mechanisms that govern physical navigation of DCs remains incomplete. Here we identify the unconventional myosin Myo10 as a critical regulator of DC trafficking. We show that loss of Myo10 attenuates FITC-induced contact hypersensitivity and reduces the efficiency of in vivo DC migration and egress from dermal explants but notably has no effect on antigen uptake or in vitro T cell priming. We further","pubDate":"2026-10-20","url":"https://www.biorxiv.org/content/10.64898/2026.10.17.755813v1?rss=1"},"indexado":"2026-10-20T14:45:48.401Z"}}