{"ok":true,"nota":{"id":"2432f0cc1108b701","slug":"resonancias-detectan-dano-en-la-medula-cervical-de-pacientes-con-mucop-2432f0","titulo":"Resonancias detectan daño en la médula cervical de pacientes con mucopolisacaridosis antes de que aparezcan sí","resumen":"Un estudio prospectivo analizó resonancias magnéticas de la médula espinal cervical en 17 pacientes con mucopolisacaridosis tipo I, 3 con tipo VI y 19 controles sanos. Midieron tanto el tamaño como la microestructura del tejido nervioso.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Nestrasil, I., Lenglet, C., Krasovec, I., Mueller, B. A., Ahmed, A., Bondy, M. T., Labounkova, I., Chekouo, T., Svatkova","url":"https://www.medrxiv.org/content/10.64898/2026.10.21.26365852v1?rss=1","imagen":"/hoy/portada/2432f0cc1108b701","tema":"salud","subtemas":["mucopolisacaridosis","médula espinal","resonancia magnética","enfermedades raras","mielopatía"],"entidades":[],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-22T04:37:56.220Z","hash":"604f75bdf30b9f5f1943ed219dc2a5c1a77299a24051dc6c3d64d95fafe6843a","tsa":{"time":"Oct 22 04:38:37 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Estas enfermedades raras pueden dañar la médula cervical de forma irreversible, y detectar el daño a tiempo es clave para conservar la movilidad. Medir la microestructura del tejido podría anticipar complicaciones que hoy se ven tarde, algo valioso para familias que siguen a sus hijos con estos diagnósticos. La muestra es muy chica, sobre todo en el tipo VI, así que hacen falta estudios más grandes.","quienFirma":"medRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"604f75bdf30b9f5f1943ed219dc2a5c1a77299a24051dc6c3d64d95fafe6843a","sello":"6fee1d079290a7dd9383bfb088a86d7728337162a129d54ceebc513ec03948f0","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573763,"aleatorio":"ac1ab9766ef209323093f9521e7402b29370fa8f04af200361451518fae9c9b2","tiempo":"2026-10-22T04:38:30.000Z"},"nist":{"cadena":2,"pulso":1994087,"salida":"2CAE0B0247F8B2C1365D5848B4971A88B86F8096596AB659C9B46851CC37B71B43230BE62392778D57CA4D0DAE3440419DC67D4E27A84A89E3AA5B314736F2A3","tiempo":"2026-10-22T04:38:00.000Z"},"noAntes":"2026-10-22T04:38:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 04:38:37 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Structural damage of the cervical spinal cord within and beyond the maximal compression area in mucopolysaccharidosis types I and VI","descripcion":"Background: Cervical spinal cord (CSC) compression and myelopathy are frequent, severe complications in mucopolysaccharidosis (MPS) types I and VI. Early detection is critical to prevent irreversible neurological deficits and preserve quality of life. This prospective study aimed to identify quantitative neuroimaging biomarkers of structural CSC damage and myelopathy in MPS I and VI. Methods: Structural and diffusion magnetic resonance imaging (MRI) of the CSC was analyzed in 17 MPS I patients, 3 MPS VI patients (19{+/-}7 years), and 19 case-matched healthy controls (20{+/-}7 years). CSC macrostructure (cross-sectional area, diameters) and microstructure (fractional anisotropy [FA], radial [","pubDate":"2026-10-21","url":"https://www.medrxiv.org/content/10.64898/2026.10.21.26365852v1?rss=1"},"indexado":"2026-10-22T04:37:56.220Z"}}