{"ok":true,"nota":{"id":"23e409d60db20611","slug":"cientificos-describen-la-estructura-de-la-proteina-del-virus-bundibugy-23e409","titulo":"Científicos describen la estructura de la proteína del virus Bundibugyo, que causa un brote de ébola en curso","resumen":"Investigadores diseñaron una versión estable de la proteína de superficie del virus Bundibugyo y determinaron su estructura tridimensional con microscopía crioelectrónica. Analizaron también cómo la reconoce un anticuerpo neutralizante.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Addetia, A., Uriu, K., Stewart, C., Sprouse, K. R., Kaku, Y., Kibria, M. G., Putri, O., Shah, S. T., Fukushima, Y., Kawa","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.761020v1?rss=1","imagen":"/hoy/portada/23e409d60db20611","tema":"salud","subtemas":["ebola","bundibugyo","vacunas","brotes epidemicos","virologia"],"entidades":["Bundibugyo","República Democrática del Congo","Uganda","EBOV-515"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T00:00:00.000Z","indexTs":"2026-10-23T18:12:31.737Z","hash":"1517e5f9669d4e0b58e6054eea715602b63a14159afda5045516eeecc74010f4","tsa":{"time":"Oct 23 18:13:30 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":1,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"El brote en el Congo y Uganda ya superó los siete mil casos, y todavía no hay vacunas ni tratamientos específicos para esta variante. Conocer la forma exacta de la proteína es el punto de partida para diseñar esas defensas. Para el público argentino, es una noticia que se sigue desde lejos, pero que puede volverse relevante si el virus se expande. La carrera contra el tiempo ya empezó en el laboratorio.","quienFirma":"Institución no especificada en el resumen (preprint de bioRxiv)","confianza":"preprint","consulta":null},"sello":{"hash":"1517e5f9669d4e0b58e6054eea715602b63a14159afda5045516eeecc74010f4","sello":"f237999faf156b63d18513100ae4dc823a5628ce13c564131f85074d36fc3c86","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6578272,"aleatorio":"e504aca3fcd7243fddbec8b88f1c51dc96cb1f827ccda23c013f3b302f3c69ab","tiempo":"2026-10-23T18:13:00.000Z"},"nist":{"cadena":2,"pulso":1996329,"salida":"880EE1B503674E57D0E81D7CEC0FFDBB3A3BB5CD5A62E05BB575BBCB9E2DB29F611799CDCF1B120D62E8DF3A39AE0D1B9935A0A198FC708C5974107E51CFF0C4","tiempo":"2026-10-23T18:12:00.000Z"},"noAntes":"2026-10-23T18:13:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 18:13:30 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Structure and antigenicity of the 2026 Bundibugyo virus glycoprotein","descripcion":"An outbreak of ebolavirus disease caused by a new zoonotic spillover of Bundibugyo virus (BDBV) is currently spreading at an unprecedented pace in the Democratic Republic of the Congo and Uganda. The outbreak has resulted in 7,733 cases with a case-fatality ratio of 48%, yet no BDBV-specific vaccines or therapeutics are available. The ebolavirus glycoprotein (GP) promotes viral entry and is the target of neutralizing antibodies and vaccine development. Here, we engineered a soluble, prefusion-stabilized GP trimer from a contemporary BDBV isolate and determined its cryo-electron microscopy structure bound to the broadly neutralizing antibody EBOV-515. It reveals the molecular basis for EBOV-5","pubDate":"2026-10-23","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.761020v1?rss=1"},"indexado":"2026-10-23T18:12:31.737Z"}}