{"ok":true,"nota":{"id":"1f5e18e53f66af98","slug":"las-mitocondrias-cambian-su-estructura-interna-cuando-falla-la-lectura-1f5e18","titulo":"Las mitocondrias cambian su estructura interna cuando falla la lectura de su ARN","resumen":"Científicos observaron con microscopios de altísima resolución las mitocondrias, las centrales de energía de la célula, cuando tienen un defecto en el procesamiento de su ARN. Hallaron que la enzima que produce energía se desplaza de su lugar habitual y que la estructura interna del órgano se deforma.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Kakudji, E. V., Rose, K. M., Lee, J., Herrmann, E., Gatti, P., Hurley, J. H., Lewis, S. C.","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.759735v1?rss=1","imagen":"/hoy/portada/1f5e18e53f66af98","tema":"ciencia","subtemas":["mitocondrias","biología celular","energía celular","microscopía","enfermedades mitocondriales"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T22:39:37.287Z","hash":"eaa066443d4eb3e7c3143cd5386b257b26c9c324d204842cf634fda181d2c796","tsa":{"time":"Oct 21 22:40:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Las mitocondrias son el motor de casi todas nuestras células, y cuando se desordenan aparecen muchas enfermedades. Este hallazgo muestra que no solo falla la cantidad de energía, sino también la arquitectura interna que la produce, algo que cambia la forma en que se piensa el problema. Para un lector de acá, sirve para entender por qué ciertas enfermedades raras o ligadas al envejecimiento son tan difíciles de tratar. El trabajo se hizo sobre células en el laboratorio, con imágenes de muy alto detalle pero en un contexto controlado.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"eaa066443d4eb3e7c3143cd5386b257b26c9c324d204842cf634fda181d2c796","sello":"c4563708690dd1982a760321bbadc0d6ce7cc3c4b4a2455c11b6ff8768fae216","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573046,"aleatorio":"f71b3db032f12c8ae2d90f38aa37ddc03a4bd072f8a3317f2962e831c62e695d","tiempo":"2026-10-21T22:40:00.000Z"},"nist":{"cadena":2,"pulso":1993728,"salida":"DBB029F00A75EEAA9AF69BB0B3207AD12D5A4EDD2136CB35D25CB332980962472F1AFBB0B247EB7DF6BE52045BC8A63F1D14E2719075ECD2BA39DE673005A0E1","tiempo":"2026-10-21T22:39:00.000Z"},"noAntes":"2026-10-21T22:40:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 22:40:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Nanoscale remodeling of mitochondrial architecture duringmtRNA surveillance failure","descripcion":"Mitochondria within a cell exhibit heterogeneity in their composition and metabolic functions, and how this specialization shapes the responses of individual organelles to stress is unclear. We applied fluorescence microscopy and in situ cryo-electron tomography to examine the composition of mitochondrial stress bodies and their relationship to inner mitochondrial membrane architecture in the context of a mitochondrial genome expression defect. We discovered that defective mitochondrial RNA processing prompted a loss of inner membrane domain identity, leading to the mislocalization of ATP synthase from cristae edges to the boundary membrane, perturbed cristae morphometrics, and complete cris","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.759735v1?rss=1"},"indexado":"2026-10-21T22:39:37.287Z"}}