{"ok":true,"nota":{"id":"1f5a93c0ab1d62e5","slug":"una-proteina-del-tejido-conectivo-hace-que-las-celulas-de-la-piel-tire-1f5a93","titulo":"Una proteína del tejido conectivo hace que las células de la piel tiren más fuerte al cicatrizar","resumen":"Investigadores cultivaron fibroblastos, las células que reparan la piel, sobre una superficie blanda con colágeno V o con colágeno I. Midieron qué tanta fuerza ejercían al moverse y cómo se pegaban al sustrato.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Royer, S. P., Tiwari, H., Cho, D., Ramineni, S. S., Rostami, M., Chandurkar, M., Cartagena-Rivera, A. X., Han, S. J.","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760760v1?rss=1","imagen":"/hoy/portada/1f5a93c0ab1d62e5","tema":"ciencia","subtemas":["colageno","cicatrizacion","fibroblastos","sindrome de ehlers-danlos","biomecanica celular"],"entidades":["bioRxiv","NIH/3T3"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T00:00:00.000Z","indexTs":"2026-10-23T12:03:18.526Z","hash":"7d588c9b1fe9addd0cf161cd443cd4ad16758cf09820a13584949d444f4ae7fc","tsa":{"time":"Oct 23 12:03:55 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Sobre el colágeno V, las células ejercieron cerca de un 50% más de tracción, se esparcieron más y se desprendieron y volvieron a pegarse más rápido. Esto ayuda a entender por qué personas con cierto tipo de síndrome de Ehlers-Danlos cicatrizan lento. El estudio se hizo en células de ratón sobre un material de laboratorio, así que todavía falta llevarlo a la piel humana.","quienFirma":"Universidad no especificada en el resumen (preprint en bioRxiv)","confianza":"preprint","consulta":null},"sello":{"hash":"7d588c9b1fe9addd0cf161cd443cd4ad16758cf09820a13584949d444f4ae7fc","sello":"03a8ca7fec3c720c86f82912eb1c87c67c034f70a337fbc80971675bfa933dd2","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6577533,"aleatorio":"c4aba0dd838f5aced1ee3ce73b5a8152f120dc443db083e10a01045483b7000d","tiempo":"2026-10-23T12:03:30.000Z"},"nist":{"cadena":2,"pulso":1995961,"salida":"F41B5D0D554B9AA93D86596521336D547B043E4F52A3C280F10F60EAE511ED1743D3E56670D4E53EB431734AC5B1B8CB5DCF96D1DB26F562D058604979415129","tiempo":"2026-10-23T12:03:00.000Z"},"noAntes":"2026-10-23T12:03:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 12:03:55 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Collagen V Presented at the Cell-Substrate Interface Mimics Substrate Stiffening to Enhance Fibroblast Traction, Adhesion Turnover, and Persistent Migration","descripcion":"Collagen type V (Col-V) is a minor fibrillar collagen that regulates collagen fibril assembly, and its haploinsufficiency causes classical Ehlers-Danlos syndrome, in which wound healing is delayed. Whether Col-V also changes how fibroblasts adhere to, pull on, and migrate across a collagen-presenting surface has not been tested directly. Here, we covalently coupled Col-I or Col-V to soft (2.7 kPa) silicone substrates and quantified the mechanical response of NIH/3T3 fibroblasts. On Col-V, cells generated about 1.5-fold higher traction, spread more, and formed smaller focal adhesions that each carried more force. Adhesions on Col-V assembled and disassembled faster. Single fibroblasts on Col-","pubDate":"2026-10-23","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760760v1?rss=1"},"indexado":"2026-10-23T12:03:18.526Z"}}