{"ok":true,"nota":{"id":"1c4fd36629353fc5","slug":"una-cianobacteria-marina-muy-simple-coordina-su-ciclo-diario-con-muy-p-1c4fd3","titulo":"Una cianobacteria marina muy simple coordina su ciclo diario con muy pocas herramientas","resumen":"Se analizaron proteínas, ARN, metabolitos y lípidos de la cianobacteria Prochlorococcus marinus MED4 a lo largo de un día completo. Con modelos metabólicos y estadística se buscó entender cómo logra un ciclo circadiano coordinado. Los datos muestran cómo cambian sus estados celulares en el tiempo.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Rozum, J. C., Li, X., Kim, Y.-M., Johnson, Z. D., Sineath, W., Garcia, M., Sadler, N., Bohutskyi, P., Cheung, M., QIAN, ","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760503v1?rss=1","imagen":"/hoy/portada/1c4fd36629353fc5","tema":"ciencia","subtemas":["cianobacterias","ritmos circadianos","oceanos","biologia molecular","metabolismo"],"entidades":["Prochlorococcus marinus MED4"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T22:39:37.287Z","hash":"038112aa8147974d1671c04065bb94c8b1e41490b86ce17c4faaf8115aba741d","tsa":{"time":"Oct 21 22:40:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Esta bacteria es una de las más abundantes del océano y produce buena parte del oxígeno que respiramos, y aun así funciona con un repertorio genético mínimo. Entender cómo organiza su día con tan pocos recursos ayuda a comprender la base de la vida fotosintética en el planeta. Es un trabajo de biología básica sin aplicaciones inmediatas para la vida cotidiana.","quienFirma":"Institución no identificada en el texto disponible","confianza":"preprint","consulta":null},"sello":{"hash":"038112aa8147974d1671c04065bb94c8b1e41490b86ce17c4faaf8115aba741d","sello":"d864a975a75d034ac97120acb0f142c2bdc9cd692b057050b22ac75142bc35a5","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573046,"aleatorio":"f71b3db032f12c8ae2d90f38aa37ddc03a4bd072f8a3317f2962e831c62e695d","tiempo":"2026-10-21T22:40:00.000Z"},"nist":{"cadena":2,"pulso":1993728,"salida":"DBB029F00A75EEAA9AF69BB0B3207AD12D5A4EDD2136CB35D25CB332980962472F1AFBB0B247EB7DF6BE52045BC8A63F1D14E2719075ECD2BA39DE673005A0E1","tiempo":"2026-10-21T22:39:00.000Z"},"noAntes":"2026-10-21T22:40:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 22:40:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Cell State Transitions Drive Transcriptome-Proteome Alignment in a Minimal Photoautotroph","descripcion":"The cyanobacterium Prochlorococcus marinus MED4 is a minimal photoautotroph that maintains circadian regulation despite its reduced circadian regulatory toolkit relative to other cyanobacteria. Moreover, MED4, like other small prokaryotes, has low transcript counts per cell and poor transcriptome-proteome alignment. A systems-level understanding of how MED4 uses its minimal regulatory machinery to achieve a well-coordinated circadian cycle is currently lacking. We address this knowledge gap by analyzing global proteomics, transcriptomics, metabolomics, and lipidomics collected across a circadian day. Integrating these data with statistical analyses, enzyme-constrained metabolic modeling, and","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760503v1?rss=1"},"indexado":"2026-10-21T22:39:37.287Z"}}