{"ok":true,"nota":{"id":"1a5fe90e60867fec","slug":"un-suplemento-de-fibra-vegetal-se-estudiara-en-mujeres-en-perimenopaus-1a5fe9","titulo":"Un suplemento de fibra vegetal se estudiará en mujeres en perimenopausia para ver su efecto","resumen":"El documento describe el protocolo de un ensayo que probará inulina, una fibra prebiótica, frente a placebo en mujeres en perimenopausia. Medirá microbiota intestinal, función vascular y metabolismo. Todavía no hay resultados.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Hajmir, M. M., Smith, S., Ghosh, M., Appiah, P. Y., Ciarglelio, A., Rahnavard, A., Ortega-Santos, C. P.","url":"https://www.medrxiv.org/content/10.64898/2026.11.02.26367110v1?rss=1","imagen":"/hoy/portada/1a5fe90e60867fec","tema":"salud","subtemas":["perimenopausia","microbiota intestinal","prebioticos","salud cardiovascular","ensayo clinico"],"entidades":["inulina"],"formato":"dato","entretenimiento":false,"pubTs":"2026-11-03T00:00:00.000Z","indexTs":"2026-11-04T03:03:40.418Z","hash":"01ea8d569f03e18f2822ff6d21476c0e1542f6920b0ad05a92000acccc80e0e4","tsa":{"time":"Nov  4 03:04:13 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Este trabajo no tiene hallazgos: solo explica cómo se va a investigar. Aun así, la idea de que la alimentación pueda ayudar a cuidar el corazón y los músculos en la perimenopausia interesa a millones de mujeres. Por ahora es una hipótesis con un diseño serio, que compara contra placebo sin que nadie sepa qué toma. Hasta que aparezcan datos, cualquier promesa sobre fibras como remedio sería adelantarse demasiado.","quienFirma":"medRxiv (preprint, equipo de investigación en nutrición y menopausia)","confianza":"preprint","consulta":null},"sello":{"hash":"01ea8d569f03e18f2822ff6d21476c0e1542f6920b0ad05a92000acccc80e0e4","sello":"215ca5fc74008a712a49fe6fd2e40711359c1e73993fbbee74d8cd3155b8ec37","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6611013,"aleatorio":"e496b9e372690d079e7e5c9d1954103e3e3a5e23e1bf59b670978bd00986cf94","tiempo":"2026-11-04T03:03:30.000Z"},"nist":{"cadena":2,"pulso":2012440,"salida":"755F3FCDA13D846D1DA9E99E93305AC1F693047E24F8EC4A7F7E08D1DE4AA97851B693B805BA3574D297F84BD3EBC083170BBC64784CBFACA3593515AB3E06E4","tiempo":"2026-11-04T03:02:00.000Z"},"noAntes":"2026-11-04T03:03:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Nov  4 03:04:13 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Prebiotic Inulin for Late-Reproductive Individuals (P.I.L.I. study): A Protocol for a Placebo-Blind, Cross-Over Randomized Controlled Trial","descripcion":"Background: Perimenopause is a transitional stage preceding menopause, characterized by hormonal fluctuations and physiological changes that may increase cardiometabolic risk. Emerging evidence suggests that the gut microbiome may influence these changes through estrogen metabolism and microbial metabolite production. Inulin, a prebiotic fiber that modulates the gut microbiome, may offer a targeted nutritional strategy; however, its effects during perimenopause remain largely unexplored. Objective: This proof-of-concept study evaluates the effects of short-term inulin supplementation on gut microbiome composition, microbial metabolites, vascular function, skeletal muscle health, and metaboli","pubDate":"2026-11-03","url":"https://www.medrxiv.org/content/10.64898/2026.11.02.26367110v1?rss=1"},"indexado":"2026-11-04T03:03:40.418Z"}}