{"ok":true,"nota":{"id":"1a3d47e2ea894968","slug":"la-forma-de-las-nanoparticulas-de-arn-mensajero-cambia-cuanto-y-cuanto-1a3d47","titulo":"La forma de las nanopartículas de ARN mensajero cambia cuánto y cuánto dura su efecto","resumen":"Investigadores modificaron la composición de lípidos de las nanopartículas que transportan ARN mensajero y observaron cambios en su forma. Vieron cómo esa forma influía en la carga, la entrada a las células y la expresión del ARN.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Elsafy, S., Dulle, M., Shahzad, S., Hammoor, T., Weiler, M., Peacock, B., Brealey, J., Metselaar, J. M., Lammers, T., So","url":"https://www.biorxiv.org/content/10.64898/2026.10.18.759824v1?rss=1","imagen":"/hoy/portada/1a3d47e2ea894968","tema":"ciencia","subtemas":["nanoparticulas","arn mensajero","vacunas","farmacologia","biotecnologia"],"entidades":["DSPC"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-23T06:48:38.804Z","hash":"00bbd9317b4c70f94574bdb9483df3bcf9de680121dfb67cd2257b5c57a16cdb","tsa":{"time":"Oct 23 06:48:59 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Las vacunas y terapias de ARN mensajero viajan dentro de nanopartículas de grasa, y hasta ahora el foco estaba en la receta química más que en la forma de esas partículas. Este trabajo muestra que pequeños cambios de forma alteran cuánto ARN llega a las células y cuánto tiempo dura el efecto. Para el desarrollo de futuros tratamientos, eso abre una variable nueva de ajuste. Es un estudio de laboratorio, así que todavía queda un largo camino hasta aplicaciones en personas.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"00bbd9317b4c70f94574bdb9483df3bcf9de680121dfb67cd2257b5c57a16cdb","sello":"d25e24d8ddc12565fb45bdec64049d092c06de94b9b9f005d026bc2046290649","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6576903,"aleatorio":"8e583525a288ba13cde66d0d6539d282d867cec58f75a0217a855687a27f9649","tiempo":"2026-10-23T06:48:30.000Z"},"nist":{"cadena":2,"pulso":1995651,"salida":"AA82134D649B7B25F10D77FD67053808011261EF94B49E048C931DF7D357E824C95C66604E50CE6E37F934A39EE493177DEA66983586EA3E4667145C3C8919D6","tiempo":"2026-10-23T06:48:00.000Z"},"noAntes":"2026-10-23T06:48:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 06:48:59 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Lipid nanoparticle shape and morphology determine the magnitude and duration of mRNA transfection","descripcion":"Lipid nanoparticles (LNP) are widely used for nucleic acid delivery, with current optimization efforts mainly focusing on refining formulation features, enabling extrahepatic targeting, and improving therapeutic efficacy. Particle shape and internal architecture are variables often overlooked in LNP design, although they critically influence particle stability, biodistribution, cellular uptake, and transfection. Here, we investigate how formulation and process parameters impact LNP shape, morphology, and internal structure, and how these structural features, in turn, influence mRNA loading, cell uptake, and expression. We demonstrate that modulation of lipid composition by increasing DSPC co","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.18.759824v1?rss=1"},"indexado":"2026-10-23T06:48:38.804Z"}}