{"ok":true,"nota":{"id":"19453533fc77c2fe","slug":"crean-en-laboratorio-un-modelo-de-tejido-cerebral-que-conecta-el-hipoc-194535","titulo":"Crean en laboratorio un modelo de tejido cerebral que conecta el hipocampo con la corteza prefrontal","resumen":"Armaron un cultivo de tejido que reproduce la conexión entre el hipocampo y la corteza prefrontal. Comprobaron con trazadores y análisis ultraestructurales que las fibras crecen y forman sinapsis, y que las células responden a la estimulación.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Stoehr, P., Grigoryan, G., Lenz, M., Vlachos, A.","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760475v1?rss=1","imagen":"/hoy/portada/19453533fc77c2fe","tema":"ciencia","subtemas":["neurociencia experimental","hipocampo","corteza prefrontal","cultivos de tejido","plasticidad sinaptica"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T10:38:41.125Z","hash":"92f142c48e3e9762f5f1b9ca1bbc1dfa135ab705f2e78a2048bd1749108d8adc","tsa":{"time":"Oct 22 10:39:10 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Para estudiar cómo se forman y cambian los circuitos de memoria y emoción, hasta ahora había que trabajar con animales o con fragmentos aislados. Un modelo de laboratorio permite controlar las condiciones y repetir experimentos con mayor precisión. Todavía es un sistema simplificado, lejos de un cerebro completo.","quienFirma":"Preprint en bioRxiv (institución principal no identificada en la descripción)","confianza":"preprint","consulta":null},"sello":{"hash":"92f142c48e3e9762f5f1b9ca1bbc1dfa135ab705f2e78a2048bd1749108d8adc","sello":"82304deff3df10b43e8f0919835093aa19fc692d828e75ee42cafba7d5d6e7e0","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6574483,"aleatorio":"9801d1332798cbede2bf7a79e77928f4f345c08d34dd79d1c4c9c9c73783e9de","tiempo":"2026-10-22T10:38:30.000Z"},"nist":{"cadena":2,"pulso":1994441,"salida":"917B00588BBAF41DD8C461E7D93EA47DC73C00983776285722380061C2505D68D1C49D178A1E9E1A422EEA35DB6367141AB79828DD0F9592CE1805F752B02469","tiempo":"2026-10-22T10:32:00.000Z"},"noAntes":"2026-10-22T10:38:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 10:39:10 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"An organotypic hippocampo-prefrontal co-culture model for studying long-range connectivity and circuit plasticity","descripcion":"The hippocampal projection to the medial prefrontal cortex (mPFC) is a key component of brain networks involved in cognition and emotion. Here, we establish and validate an organotypic entorhino-hippocampo-prefrontal co-culture model that enables experimental investigation of long-range circuit connectivity and plasticity under controlled in vitro conditions. Anatomical tracing, viral labeling, and ultrastructural analyses demonstrate hippocampal axonal projections and synapse formation within the mPFC. Functional connectivity was supported by hippocampal CA1 stimulation, which evoked postsynaptic responses in 90.6% of recorded layer 2/3 mPFC pyramidal neurons. Intrinsic membrane properties ","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760475v1?rss=1"},"indexado":"2026-10-22T10:38:41.125Z"}}