{"ok":true,"nota":{"id":"17251f822ec4747f","slug":"el-fentanilo-cronico-calma-la-ansiedad-en-ratas-pero-de-forma-distinta-17251f","titulo":"El fentanilo crónico calma la ansiedad en ratas, pero de forma distinta en machos y hembras","resumen":"Investigadores expusieron ratas macho y hembra a fentanilo durante un tiempo prolongado mediante minibombas. Midieron su ansiedad, actividad y dependencia en un campo abierto antes y después del tratamiento.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Caglayan, L., Zeyl, F., Gamba, E., Febo, M., Bruijnzeel, A. W.","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760254v1?rss=1","imagen":"/hoy/portada/17251f822ec4747f","tema":"salud","subtemas":["fentanilo","adicción a opioides","ansiedad","diferencias por sexo","modelos animales"],"entidades":["Wistar","bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T00:00:00.000Z","indexTs":"2026-10-23T12:03:18.526Z","hash":"b968b828a2704e9163e318cba9f253572da99aa8fbb88981eb2e7bbcc15db9de","tsa":{"time":"Oct 23 12:03:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"motor","registro":"hallazgo","porQueImporta":"Los resultados sugieren que el fentanilo puede bajar la ansiedad en animales dependientes, y que el efecto no es igual en machos y hembras. Para la Argentina, donde el consumo indebido de opioides preocupa cada vez más, esto importa porque el alivio aparente puede ser parte del círculo de la adicción. Es un estudio con ratas, así que no se traslada directamente a personas.","quienFirma":"bioRxiv (preprint; investigación en modelos animales con ratas Wistar)","confianza":"preprint","consulta":{"pregunta":"¿Creés que las drogas que alivian el dolor pueden generar más problemas que beneficios?"}},"sello":{"hash":"b968b828a2704e9163e318cba9f253572da99aa8fbb88981eb2e7bbcc15db9de","sello":"16851222694f8758480fa594559353ad997791a2ce1352dfa6e814a2df1d6294","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6577533,"aleatorio":"c4aba0dd838f5aced1ee3ce73b5a8152f120dc443db083e10a01045483b7000d","tiempo":"2026-10-23T12:03:30.000Z"},"nist":{"cadena":2,"pulso":1995961,"salida":"F41B5D0D554B9AA93D86596521336D547B043E4F52A3C280F10F60EAE511ED1743D3E56670D4E53EB431734AC5B1B8CB5DCF96D1DB26F562D058604979415129","tiempo":"2026-10-23T12:03:00.000Z"},"noAntes":"2026-10-23T12:03:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 12:03:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Chronic fentanyl induces sex-specific anxiolytic-like effects in opioid-dependent rats","descripcion":"Fentanyl is used as a treatment for severe pain, and it is a major contributor to opioid misuse and overdose fatalities. While it has been established that opioids are widely misused for their euphoric effects, little is known about the effects of chronic fentanyl exposure on anxiety-like behavior. We determined the effects of chronic fentanyl on anxiety-like behavior, locomotor activity, dependence, and body weight in adult male and female Wistar rats (n = 8 per sex and treatment) that received saline or fentanyl (0.6 mg/kg/day) via minipumps. Locomotor activity was measured in a small open field (SOF) before pump implantation. After implantation, rats were retested in the SOF, evaluated fo","pubDate":"2026-10-23","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760254v1?rss=1"},"indexado":"2026-10-23T12:03:18.526Z"}}