{"ok":true,"nota":{"id":"16d5f656d25bda0d","slug":"en-personas-con-la-variante-apoe-4-el-agrandamiento-del-corazon-afecta-16d5f6","titulo":"En personas con la variante APOE ε4, el agrandamiento del corazón afecta más al cerebro con los años","resumen":"Investigadores de Framingham siguieron a más de 1.300 personas y compararon cambios en la aurícula izquierda del corazón con imágenes del cerebro. Vieron que la variante genética APOE ε4 cambia esa relación.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Badea, A., Xu, J., Laskowitz, D. T., Badea, C. T.","url":"https://www.medrxiv.org/content/10.64898/2026.10.14.26365550v1?rss=1","imagen":"/hoy/portada/16d5f656d25bda0d","tema":"ciencia","subtemas":["cardiologia","envejecimiento cerebral","genetica","apoe","resonancia magnetica"],"entidades":["Framingham Heart Study","Estados Unidos"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-20T23:32:18.927Z","hash":"95783e87057a3c7d9c93301095a2cd110fba83b0a5ac6e9506ef5bae07a6d0ab","tsa":{"time":"Oct 20 23:33:03 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Un corazón que se agranda en una de sus cavidades puede asociarse a cambios en el cerebro, pero no de la misma forma en todos. Esto sugiere que la genética influye en cómo envejecen juntos el corazón y la cabeza. Para alguien que tiene un familiar con esa variante, la pregunta de cómo cuidar la presión y la salud cardiovascular gana peso. El estudio es observacional y no demuestra causa, así que todavía no alcanza para decidir tratamientos.","quienFirma":"Framingham Heart Study (Boston University y Boston Medical Center)","confianza":"preprint","consulta":null},"sello":{"hash":"95783e87057a3c7d9c93301095a2cd110fba83b0a5ac6e9506ef5bae07a6d0ab","sello":"068cbc628a09d3b55f33fd2151636192461bdd87adea8a464180de31d4903cb3","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6570272,"aleatorio":"bda24f270320f1e2527293c15ec727a66bdf246506dc957c7c9b6bd88c84b428","tiempo":"2026-10-20T23:33:00.000Z"},"nist":{"cadena":2,"pulso":1992341,"salida":"FA817D353D94A91CF41B4C174AAAB25209FED37DED6709559D325A28B103253A89D243C5C71B384CB4111753AA993F97FAC5CFB1C3257FDFA18ADA31FEE94D9A","tiempo":"2026-10-20T23:32:00.000Z"},"noAntes":"2026-10-20T23:33:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 20 23:33:03 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"APOE ε4 Modifies the Association of Left Atrial Remodeling With Brain Aging","descripcion":"INTRODUCTION: Whether APOE e4 modifies relationships between subclinical cardiac phenotypes and brain structure is unknown. METHODS: In Framingham Heart Study Offspring participants, we related antecedent echocardiographic remodeling (Examinations 4-6) to repeated brain MRI, and cardiac magnetic resonance phenotypes to regional cortical morphometry, testing cardiac x APOE e4 interactions with false-discovery-rate (FDR) correction and permutation testing of the regional screen. RESULTS: APOE e4 modified the association between antecedent left atrial (LA) remodeling and subsequent lateral ventricular expansion (beta=-0.00858, P=1.45 x 10^-4, q=0.0023; N=1,305; 3,787 MRI observations), the only","pubDate":"2026-10-20","url":"https://www.medrxiv.org/content/10.64898/2026.10.14.26365550v1?rss=1"},"indexado":"2026-10-20T23:32:18.927Z"}}