{"ok":true,"nota":{"id":"11fb022e3cec3aca","slug":"un-campo-electrico-aplicado-durante-la-isquemia-reduce-el-dano-tempran-11fb02","titulo":"Un campo eléctrico aplicado durante la isquemia reduce el daño temprano en riñones de cerdos","resumen":"Investigadores sometieron a cerdos a una interrupción de 90 minutos del flujo sanguíneo renal y les aplicaron un campo eléctrico modulado durante ese lapso. Midieron marcadores de daño renal y analizaron el tejido.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Li, M., Ni, R., Williams, K., Hall, N., Parris, C., Esquivel, C., Tran, M., Fu, L., Subramanian, V., Dhanireddy, K., Wan","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760575v1?rss=1","imagen":"/hoy/portada/11fb022e3cec3aca","tema":"salud","subtemas":["insuficiencia renal","trasplantes","cirugía","investigación animal"],"entidades":["Yorkshire pigs"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-25T00:00:00.000Z","indexTs":"2026-10-26T04:38:59.737Z","hash":"69ad00b1821ec43ec6b555815819cb3924dc2355db2f6823fe3662b542815b01","tsa":{"time":"Oct 26 04:39:34 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"En el experimento, los riñones tratados mostraron menos daño temprano que los que no recibieron el campo, medido con creatinina y otros marcadores. Esto importa porque hoy no existe ningún fármaco aprobado para la lesión renal aguda, un problema frecuente en cirugías y en pacientes críticos. Una técnica que proteja el órgano durante el corte del flujo podría cambiar el pronóstico de muchas personas. Sin embargo, son apenas doce animales y el resultado todavía no llegó a humanos.","quienFirma":"Institución no identificada en el preprint","confianza":"preprint","consulta":null},"sello":{"hash":"69ad00b1821ec43ec6b555815819cb3924dc2355db2f6823fe3662b542815b01","sello":"06d680849f40693fa9e566b3119c1c3f3b586d54a0c9387b749f3b66b62dad48","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6585285,"aleatorio":"eb615b82e2756a5239e083f84b3ee4cca3905aac866b8093e58c2109a1b6ba65","tiempo":"2026-10-26T04:39:30.000Z"},"nist":{"cadena":2,"pulso":1999836,"salida":"8A9648E112C884754C4BA14CEABA6D2AFA1376B135546D6B47CC74503EB82E37828C3076A34D73719D10498F27CA2A2BF907EE9977E40FD1B83A29275B0FFCE0","tiempo":"2026-10-26T04:39:00.000Z"},"noAntes":"2026-10-26T04:39:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 04:39:34 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"A synchronization modulation electric field reduces early ischemic kidney injury in pigs and suppresses a stress and inflammatory program without detectable leukocyte accumulation","descripcion":"Background. Acute kidney injury has no approved drug treatment. A synchronization modulation electric field (SMEF) keeps Na+/K+-ATPase working when ATP is scarce, and protects the rodent kidney from ischemia-reperfusion injury and human kidneys during cold storage. It has not been tested in a large animal in vivo, and what it changes in the tissue is unknown. Methods. Twelve female Yorkshire pigs underwent 90 min of bilateral renal pedicle occlusion and 4 h of reperfusion (n = 4 per group: sham, injury, injury plus SMEF), with the field applied during ischemia. We measured serum creatinine, blood urea nitrogen and plasma NGAL, graded tubular injury histologically, sequenced kidney RNA, and m","pubDate":"2026-10-25","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760575v1?rss=1"},"indexado":"2026-10-26T04:38:59.737Z"}}