{"ok":true,"nota":{"id":"1090603d976e8018","slug":"un-corazon-artificial-en-chip-reproduce-el-dano-que-causa-la-vuelta-de-109060","titulo":"Un corazón artificial en chip reproduce el daño que causa la vuelta de la sangre tras un infarto","resumen":"Investigadores crearon un modelo de corazón en un chip con células cardíacas de rata, al que le provocaron falta de oxígeno y luego restablecieron el flujo. Midieron el daño en la estructura, la bioquímica y la capacidad de contracción del tejido.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Tran, K., Vincent, A. R., Whitmer, C. S., Khayat, R. N., Grosberg, A.","url":"https://www.biorxiv.org/content/10.64898/2026.10.23.761466v1?rss=1","imagen":"/hoy/portada/1090603d976e8018","tema":"ciencia","subtemas":["cardiologia","infarto","medicina regenerativa","modelos en chip","investigacion preclinica"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-29T00:00:00.000Z","indexTs":"2026-10-30T02:15:57.412Z","hash":"5b3897d64d1fa8bd21b4a366777fb1a00a00e858f4b97e8d516527ade3047a2c","tsa":{"time":"Oct 30 02:16:47 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hasta ahora muchos tratamientos que reducían el tamaño del infarto en animales no mejoraban la salud de los pacientes, porque se evaluaban solo con una medida. Un modelo que mira tres aspectos del daño a la vez permite probar fármacos de forma más realista antes de llegar a personas. Para quien tiene factores de riesgo cardíaco, eso puede acortar el camino hacia terapias que realmente funcionen. Un límite importante: el modelo usa células de rata y todavía no se validó en humanos.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"5b3897d64d1fa8bd21b4a366777fb1a00a00e858f4b97e8d516527ade3047a2c","sello":"b068a8c2f1220856b72358a730360474f6d81f79d7c1484030be90c4af3d62b1","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6596518,"aleatorio":"699b34e2b8f819688a5e5647392621c2c50bb6c1cb8843ed6f9594063d15ce1d","tiempo":"2026-10-30T02:16:00.000Z"},"nist":{"cadena":2,"pulso":2005193,"salida":"EE2BEC57C11F41F5E1889E5B20E4D0CE683CF98029EE4CC55D6F29A7C3281FB62E60F1A84BCAFE29537263A94DEDDC7C786FF36E26242F66A70175F4C23DBB95","tiempo":"2026-10-30T02:15:00.000Z"},"noAntes":"2026-10-30T02:16:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 30 02:16:47 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"AN INTEGRATED HEART-ON-A-CHIP NAM RESOLVES DISTINCT CLINICAL PHENOTYPES OF MYOCARDIAL ISCHEMIA-REPERFUSION INJURY","descripcion":"Background: Reperfusion is required for myocardial salvage yet itself injures the heart, and cardioprotective interventions that reduce infarct size experimentally have repeatedly failed to improve outcomes in patients. These interventions are evaluated against viability or infarct size alone, whereas ischemia-reperfusion (I/R) injury produces structural, biochemical, and contractile dysfunction in the same tissue. No in vitro new approach methodology (NAM), however, resolves all three within one system. Methods: A NAM was created within a heart-on-a-chip platform, which was constructed by culturing neonatal rat ventricular myocytes (NRVMs) on muscular thin films. Cardiomyocytes were subject","pubDate":"2026-10-29","url":"https://www.biorxiv.org/content/10.64898/2026.10.23.761466v1?rss=1"},"indexado":"2026-10-30T02:15:57.412Z"}}