{"ok":true,"nota":{"id":"0ff0a1e5b3c01c01","slug":"un-metodo-nuevo-permite-detectar-perdidas-de-partes-del-adn-en-celulas-0ff0a1","titulo":"Un método nuevo permite detectar pérdidas de partes del ADN en células individuales","resumen":"Investigadores desarrollaron una herramienta matemática para leer el ADN de células sueltas, aunque la secuenciación da poca información por célula. El método identifica zonas del genoma donde se perdió una de las dos copias heredadas.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Ridgley, T., Chovanec, P., He, S., Yin, Y.","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760240v1?rss=1","imagen":"/hoy/portada/0ff0a1e5b3c01c01","tema":"ciencia","subtemas":["genetica","adn celular","cancer","envejecimiento","secuenciacion"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-24T00:00:00.000Z","indexTs":"2026-10-24T15:36:22.700Z","hash":"2c20c07e2022afbc5a3c902dd0cf0c97956d5d0cae511ec44455558999aee704","tsa":{"time":"Oct 24 15:36:50 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Las células pueden perder copias de sus genes con el envejecimiento y en algunos tumores, y eso puede dejar expuestas mutaciones dañinas. Con esta técnica se puede estudiar ese proceso célula por célula, algo que antes costaba mucho. Para la salud, esto ayuda a entender mejor cómo empieza el cáncer, aunque todavía falta mucho camino para llevarlo a la práctica clínica. El trabajo todavía no fue revisado por pares.","quienFirma":"Universidad de Washington (según el preprint)","confianza":"preprint","consulta":null},"sello":{"hash":"2c20c07e2022afbc5a3c902dd0cf0c97956d5d0cae511ec44455558999aee704","sello":"bebd5c5b6ca9a6d8ac29d8beeee6722c7780992176038b5534458b279e1099b7","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6580838,"aleatorio":"d8ef5a9dd5dcb7ecde960120181f6d2da35de75b230ed4ca2c75f2e3041031ed","tiempo":"2026-10-24T15:36:00.000Z"},"nist":{"cadena":2,"pulso":1997612,"salida":"0525492476BBCEBBD988C497DA276C7A3F76D40712E146911682FB4E3ECC1DD0525787CE88330588DA3B0EF9D7839EBA4BAC598FA8667FB3007E6D6E35A002BD","tiempo":"2026-10-24T15:35:00.000Z"},"noAntes":"2026-10-24T15:36:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 24 15:36:50 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Robust Chromosome Segmentation in Sparse Single-Cell Whole-Genome Sequencing Using a k-Segment Constrained Hidden Markov Model","descripcion":"Genome integrity is essential for cellular and organismal fitness. Loss of heterozygosity (LOH), which eliminates the buffering effect of heterozygosity and can expose deleterious recessive alleles, is an important form of somatic genome alteration associated with aging and tumorigenesis. To characterize LOH across cell populations, we use sci-L3, a high-throughput combinatorial-indexing approach for single-cell whole-genome sequencing (WGS). The throughput, however, comes at the cost of sparse coverage of individual genomes, complicating LOH inference from phased heterozygous sites. We therefore developed a k-segment constrained hidden Markov model (HMM) that explicitly limits the maximum n","pubDate":"2026-10-24","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760240v1?rss=1"},"indexado":"2026-10-24T15:36:22.700Z"}}