{"ok":true,"nota":{"id":"0f0f252752679f35","slug":"descubren-un-freno-natural-que-los-vasos-sanguineos-usan-para-no-crece-0f0f25","titulo":"Descubren un freno natural que los vasos sanguíneos usan para no crecer de más","resumen":"Investigadores identificaron que la proteína CD160, presente en las células que recubren los vasos sanguíneos, frena el crecimiento desordenado de nuevos vasos. El mecanismo depende de la proteína LRP1 y de un proceso de autofagia celular.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Aziz, A.-I., Mocquery-Corre, M., Berquand, A., Thevenard-Devy, J., Martins, A., Hachet, C., Potteaux, S., Merrouche, Y.,","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760050v1?rss=1","imagen":"/hoy/portada/0f0f252752679f35","tema":"salud","subtemas":["angiogénesis","cáncer","vasos sanguíneos","inmunología","investigación básica"],"entidades":["CD160","LRP1","bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T00:00:00.000Z","indexTs":"2026-10-23T18:12:31.737Z","hash":"132d854954a5f67780e459a759e9dd4ceda3d4a334cea0f5bc21a2973a4dca12","tsa":{"time":"Oct 23 18:13:32 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Encontrar uno de esos frenos abre la posibilidad de potenciarlo en lugar de solo bloquear el exceso. Todavía es investigación en etapa temprana, probada en células y no en personas. Lo que falta saber es si ese freno funciona igual en un organismo completo.","quienFirma":"bioRxiv (preprint; institución de los autores no especificada en el resumen)","confianza":"preprint","consulta":null},"sello":{"hash":"132d854954a5f67780e459a759e9dd4ceda3d4a334cea0f5bc21a2973a4dca12","sello":"f284c5268231e3e97252b6639477774ceae2bc0ceb66027420ce340ec224ae7d","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6578272,"aleatorio":"e504aca3fcd7243fddbec8b88f1c51dc96cb1f827ccda23c013f3b302f3c69ab","tiempo":"2026-10-23T18:13:00.000Z"},"nist":{"cadena":2,"pulso":1996329,"salida":"880EE1B503674E57D0E81D7CEC0FFDBB3A3BB5CD5A62E05BB575BBCB9E2DB29F611799CDCF1B120D62E8DF3A39AE0D1B9935A0A198FC708C5974107E51CFF0C4","tiempo":"2026-10-23T18:12:00.000Z"},"noAntes":"2026-10-23T18:13:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 18:13:32 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"CD160 is an inducible endothelial checkpoint that suppresses sprouting angiogenesis through LRP1-dependent autophagy","descripcion":"Pathological angiogenesis is a hallmark of cancer and other chronic diseases, yet therapeutic strategies remain largely focused on blocking pro-angiogenic signals rather than restoring endogenous mechanisms that restrain endothelial sprouting. The identification of endothelial checkpoints capable of limiting pathological vessel growth therefore remains an important unmet need. CD160 is a glycosylphosphatidylinositol-anchored immunoglobulin-superfamily receptor of cytotoxic lymphocytes and an inhibitory checkpoint receptor on CD4 T cells. It is also present on endothelium and has been targeted therapeutically. Here, we identify CD160 as an inducible endothelial checkpoint that emerges in resp","pubDate":"2026-10-23","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760050v1?rss=1"},"indexado":"2026-10-23T18:12:31.737Z"}}