{"ok":true,"nota":{"id":"02b57f32af3a784f","slug":"personas-con-psoriasis-comparten-genes-de-riesgo-con-varias-enfermedad-02b57f","titulo":"Personas con psoriasis comparten genes de riesgo con varias enfermedades del corazón","resumen":"Investigadores cruzaron datos genéticos de psoriasis con los de siete enfermedades cardiovasculares en personas de ascendencia europea. Identificaron 167 zonas del genoma asociadas al riesgo compartido.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Antonatos, C., Georgalaki, E., Tzoulaki, I., Vasilopoulos, Y.","url":"https://www.medrxiv.org/content/10.64898/2026.10.19.26365878v1?rss=1","imagen":"/hoy/portada/02b57f32af3a784f","tema":"salud","subtemas":["psoriasis","enfermedades cardiovasculares","genetica","riesgo compartido","inflamacion"],"entidades":["Europa"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-20T23:32:18.927Z","hash":"688f69d9bdd2ff3f53691f919523334055eda1bed277ca5ed7df1604c88cae7c","tsa":{"time":"Oct 20 23:33:04 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Más de la mitad de las variantes genéticas vinculadas a la psoriasis también aparecen en cinco de esas enfermedades del corazón, según el modelo estadístico. Para quien convive con psoriasis, esto explica por qué los médicos suelen mirar también el sistema cardiovascular, aunque la piel sea el problema visible. El trabajo se basa en estadísticas genéticas agregadas y no en pacientes individuales, y sus conclusiones sobre mecanismos son todavía hipótesis. Igual, marca un camino para entender por qué la piel y el corazón parecen estar tan conectados.","quienFirma":"medRxiv (preprint; institución principal no identificada en el resumen)","confianza":"preprint","consulta":null},"sello":{"hash":"688f69d9bdd2ff3f53691f919523334055eda1bed277ca5ed7df1604c88cae7c","sello":"9b0998ce6e9687ae9afe3c569cdc350ef82fe4433929897294a6b5ce8da53168","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6570272,"aleatorio":"bda24f270320f1e2527293c15ec727a66bdf246506dc957c7c9b6bd88c84b428","tiempo":"2026-10-20T23:33:00.000Z"},"nist":{"cadena":2,"pulso":1992341,"salida":"FA817D353D94A91CF41B4C174AAAB25209FED37DED6709559D325A28B103253A89D243C5C71B384CB4111753AA993F97FAC5CFB1C3257FDFA18ADA31FEE94D9A","tiempo":"2026-10-20T23:32:00.000Z"},"noAntes":"2026-10-20T23:33:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 20 23:33:04 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Multivariate genetic analysis maps shared biology between psoriasis and cardiovascular diseases","descripcion":"Psoriasis is associated with increased cardiovascular morbidity, but the extent and structure of the shared genetic architecture remain incompletely understood. We integrated large-scale European-ancestry genome-wide summary statistics for psoriasis and seven cardiovascular diseases to quantify genetic overlap, model shared liability and prioritize candidate mechanisms. Psoriasis showed modest genetic correlations with all cardiovascular outcomes, but mixture modelling estimated that more than half of psoriasis-associated non-zero variants were shared with five cardiovascular diseases. Genomic structural equation modelling of a latent psoriasis-CVD factor identified 167 independent risk loci","pubDate":"2026-10-20","url":"https://www.medrxiv.org/content/10.64898/2026.10.19.26365878v1?rss=1"},"indexado":"2026-10-20T23:32:18.927Z"}}